Evaluation of plant extracts for antileishmanial activity using a mechanism-based radiorespirometric microtechnique (RAM)

Autor: John D. Tally, Daniel L. Klayman, Joan E. Jackson, Maurice M. Iwu
Rok vydání: 1992
Předmět:
Zdroj: Planta medica. 58(5)
ISSN: 0032-0943
Popis: Extracts of eleven plants used in Nigerian traditional medicine have been evaluated for possible antileishmanial activity using a radiorespirometric microtest technique based on in vitro inhibition of catabolism of 14CO2 from a battery of 14C-substrates by promastigotes. Of 13 methanol extracts tested, 5 from Gongronema latifolia, Dorstenia multiradiata, Picralima nitida, Cola attiensis, and Desmodium gangeticum, were active at concentrations of 50 micrograms/ml or less against a visceral Leishmania isolate.
Databáze: OpenAIRE