Evaluation of plant extracts for antileishmanial activity using a mechanism-based radiorespirometric microtechnique (RAM)
| Autor: | John D. Tally, Daniel L. Klayman, Joan E. Jackson, Maurice M. Iwu |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Pharmacology
Picralima Leishmania Plants Medicinal Traditional medicine Desmodium Plant Extracts Organic Chemistry Desmodium gangeticum Antiprotozoal Agents Pharmaceutical Science Biology Carbon Dioxide biology.organism_classification Moraceae Analytical Chemistry Dorstenia Complementary and alternative medicine Microtechnique Drug Discovery Cola attiensis Molecular Medicine Animals |
| Zdroj: | Planta medica. 58(5) |
| ISSN: | 0032-0943 |
| Popis: | Extracts of eleven plants used in Nigerian traditional medicine have been evaluated for possible antileishmanial activity using a radiorespirometric microtest technique based on in vitro inhibition of catabolism of 14CO2 from a battery of 14C-substrates by promastigotes. Of 13 methanol extracts tested, 5 from Gongronema latifolia, Dorstenia multiradiata, Picralima nitida, Cola attiensis, and Desmodium gangeticum, were active at concentrations of 50 micrograms/ml or less against a visceral Leishmania isolate. |
| Databáze: | OpenAIRE |
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