Muscle and intestinal damage in triathletes
| Autor: | Tomasz Pałka, Dariusz Mucha, Magdalena Żmuda-Pałka, Wanda Pilch, Małgorzata Morawska, Wioletta Mikuľáková, Anna Piotrowska, Łukasz Tota |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Male
Hydrocortisone Physiology Social Sciences 030204 cardiovascular system & hematology Pathology and Laboratory Medicine Biochemistry Cortisol Running chemistry.chemical_compound 0302 clinical medicine Animal Cells Immune Physiology Medicine and Health Sciences Psychology Myocyte Testosterone Lipid Hormones Treadmill Immune Response Innate Immune System Exercise Tolerance Multidisciplinary Myoglobin Zonulin VO2 max Sports Science Body Fluids Intestines Blood C-Reactive Protein Androgens Body Composition Cytokines Medicine Female Anatomy Cellular Types medicine.symptom Research Article Sports Adult Cholera Toxin medicine.medical_specialty Science Immunology Muscle Tissue Inflammation Biology 03 medical and health sciences Signs and Symptoms Oxygen Consumption Diagnostic Medicine Internal medicine medicine Humans Plasma Volume Protein Precursors Muscle Skeletal Swimming Aerobic capacity Behavior Steroid Hormones Muscle Cells Haptoglobins Biology and Life Sciences Cell Biology 030229 sport sciences Molecular Development Hormones Bicycling Gastrointestinal Tract Biological Tissue Endocrinology chemistry Athletes Immune System Recreation Digestive System Biomarkers Developmental Biology |
| Zdroj: | PLoS ONE, Vol 14, Iss 1, p e0210651 (2019) PLoS ONE |
| ISSN: | 1932-6203 |
| Popis: | The aim of the paper was to assess indicators of muscle and intestinal damage in triathletes. The study involved 15 triathletes whose objective for the season was to start in the XTERRA POLAND 2017 event (1,500-m swimming, 36-km cycling, and 10-km mountain running). Before the 14-week preparatory period, the competitors' body composition was measured, aerobic capacity was tested (graded treadmill test) and blood samples were collected to determine markers showing the level of muscle and intestinal damage. Subsequent tests for body composition were carried out before and after the competition. Blood samples for biochemical indicators were collected the day before the competition, after the completed race, and 24 and 48 hours later. A significant decrease in body mass was observed after completing the race (-3.1±1.5%). The mean maximal oxygen uptake level among the studied athletes equalled 4.9±0.4 L·min-1, 58.8±4.5 mL·kg-1·min-1. The significant increase in concentrations of cortisol, c-reactive protein and myoglobin after the competition, significantly correlated with the significant increase in zonulin concentration (post 1h: r = 0.88, p = 0.007, r = 0,79, p = 0.001, r = 0.78, p = 0.001, and post 12h: r = 0.75, p = 0.01, r = 0.71, p = 0.011, r = 0.83, p = 0.02). No significant changes in the concentration of tumour necrosis factor alpha among the examined competitors were noted at following stages of the study. The results of our research showed that in order to monitor overload in the training of triathletes, useful markers reflecting the degree of muscle and intestinal damage include cortisol, testosterone, testosterone to cortisol ratio, c-reactive protein, myoglobin and zonulin. Changes in muscle cell damage markers strongly correlated with changes in zonulin concentration at particular stages of the study. Thus, one can expect that the concentrations of markers depicting the level of muscle cell damage after an intense and long-lasting effort will significantly influence the level of the intestinal barrier. |
| Databáze: | OpenAIRE |
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