Epigenetic mechanisms of chronic pain
| Autor: | Giannina Descalzi, Minoru Narita, Toshikazu Ushijima, Eric J. Nestler, Daigo Ikegami, Venetia Zachariou |
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| Rok vydání: | 2015 |
| Předmět: |
Nervous system
business.industry General Neuroscience Chronic pain medicine.disease Article Epigenesis Genetic Histones Disease Models Animal Allodynia medicine.anatomical_structure Hyperalgesia Neuropathic pain microRNA medicine Animals Humans sense organs Epigenetics Chronic Pain medicine.symptom business Neuroscience Depression (differential diagnoses) |
| Zdroj: | Trends in Neurosciences. 38:237-246 |
| ISSN: | 0166-2236 |
| Popis: | Neuropathic and inflammatory pain promote a large number of persisting adaptations at the cellular and molecular level, allowing tissue or nerve damage, even if only transient, to elicit changes in cells that contribute to the development of chronic pain and associated symptoms. There is evidence that injury-induced changes in chromatin structure drive stable changes in gene expression and neural function, which may cause several symptoms, including allodynia, hyperalgesia, anxiety, and depression. Recent findings on epigenetic changes in the spinal cord and brain during chronic pain may guide fundamental advances in new treatments. In this review, we provide a brief overview of epigenetic regulation in the nervous system and then discuss the still-limited literature that directly implicates epigenetic modifications in chronic pain syndromes. |
| Databáze: | OpenAIRE |
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