Prognostic factors in patients with renal cell carcinoma: retrospective analysis of 675 cases
| Autor: | G. Malossini, Stefania Pilloni, Gaetano Mobilio, Antonio D'Amico, Nicola Maffei, Luisa Zanolla, Vincenzo Ficarra, Rita Righetti, Giovanni Novella |
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| Jazyk: | angličtina |
| Rok vydání: | 2002 |
| Předmět: |
Adult
Male medicine.medical_specialty renal cell carcinoma Time Factors Adolescent Urology medicine.medical_treatment urologic and male genital diseases Kidney Gastroenterology Metastasis prognostic factors Renal cell carcinoma Predictive Value of Tests Internal medicine Cause of Death medicine Carcinoma Humans Grading (tumors) Carcinoma Renal Cell Survival analysis Aged Neoplasm Staging Retrospective Studies Aged 80 and over business.industry Middle Aged medicine.disease Prognosis Primary tumor Survival Analysis Nephrectomy Kidney Neoplasms Surgery Italy Multivariate Analysis Disease Progression Adenocarcinoma Female business Follow-Up Studies |
| Popis: | To identify independent predictors of cause-specific survival in patients affected by renal cell carcinoma (RCC).We evaluated retrospectively 675 patients who underwent in our department from 1976 to 1999 radical nephrectomy for RCC. Pathological stage of the primary tumor (TNM, 1997) was pT1 in 326 cases (48%), pT2 in 133 (20%), pT3a in 66 (10%), pT3b in 138 (20%) and pT4 in 12 (2%). According to TNM classification (Union International Contre le Cancer (UICC), 1997) the pathological stage was I in 303 cases (45%), II in 119 (18%), III in 150 (22%) and IV in 103 (15%). Histological grading was assigned according to Fuhrman's classification in only 333 cases: G1 in 25%, G2 in 35%, G3 in 33% and G4 in 7%.Cause-specific survival was 77% at 5 years, 69% at 10 years, 64% at 15 years and 57% at 20 years. Five and 10 year cause-specific survival was, respectively 91.4 and 88.5% in pT1 tumors, 84.8 and 72.7% in pT2, 57.4 and 35.6% in pT3a, 47.2 and 33.6% in pT3b-c, and 29.6% in pT4 (P0.0001). In relation to the pathological stage according to TNM classification, 5 and 10 year cause-specific survival was, respectively 94 and 91.6% in stage I tumors, 89.7 and 78% in stage II, 63.4 and 46.4% in stage III and 28 and 16.3% in stage IV (P0.0001). In relation to the nuclear grade of the primary tumor 5 and 10 year cause-specific survival was, respectively 94 and 88% in G1 tumors, 86 and 75% in G2, 59 and 40% in G3 and 31% in G4 (P0.0001). At multivariate analysis pathological stage of the primary tumor, lymph nodes involvement, presence of distant metastases at diagnosis and nuclear grading resulted all independent predictors of cause-specific survival in patients with RCC.Pathological stage of primary tumors, lymph nodes involvement, presence of distant metastases at diagnosis and nuclear grading according to Fuhrman resulted all independent predictors of cause-specific mortality in patients with RCC. |
| Databáze: | OpenAIRE |
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