| Autor: |
Modhusudan Mondal, Shatarupa Basak, Salim Ali, Debadrita Roy, Subhadeep Saha, Biswajit Ghosh, Narendra Nath Ghosh, Khusboo Lepcha, Kanak Roy, Mahendra Nath Roy |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
RSC Advances. 12:30936-30951 |
| ISSN: |
2046-2069 |
| Popis: |
The co-evaporation approach was used to examine the host-guest interaction and to explore the cytotoxic and antibacterial properties of an important anti-cancer medication, 6-mercaptopurine monohydrate (6-MP) with β-cyclodextrin (β-CD). The UV-Vis investigation confirmed the inclusion complex's (IC) 1 : 1 stoichiometry and was also utilized to oversee the viability of this inclusion process. FTIR, NMR, and XRD, among other spectrometric techniques, revealed the mechanism of molecular interactions between β-CD and 6-MP which was further hypothesized by DFT to verify tentative outcomes. TGA and DSC studies revealed that 6-MP's thermal stability increased after encapsulation. Because of the protection of drug 6-MP by β-CD, the formed IC was found to have higher photostability. This work also predicts the release behavior of 6-MP in the presence of CT-DNA without any chemical changes. An evaluation of the complex's antibacterial activity |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
