Expression of COUP-TFII nuclear receptor in restricted GABAergic neuronal populations in the adult rat hippocampus
| Autor: | Kathleen S. Rockland, Thomas Klausberger, Michèle Studer, Theofanis Karayannis, Wai Yee Suen, Marisela Morales, Marco Capogna, Jojanneke H. J. Huck, Pablo Fuentealba, Peter Somogyi, Ryohei Tomioka |
|---|---|
| Přispěvatelé: | University of Zurich, Fuentealba, Pablo |
| Rok vydání: | 2010 |
| Předmět: |
Male
Patch-Clamp Techniques Neuroglia/metabolism Cyclohexanecarboxylic Acids Nerve Tissue Proteins/metabolism Neurons/metabolism Hippocampal formation Hippocampus COUP Transcription Factor II Rats Sprague-Dawley Amines gamma-Aminobutyric Acid COUP Transcription Factor II/metabolism Neurons Extracellular Matrix Proteins Neocortex General Neuroscience musculoskeletal neural and ocular physiology Pyramidal Cells Serine Endopeptidases 2800 General Neuroscience Cell Adhesion Molecules Neuronal/metabolism medicine.anatomical_structure Hippocampus/cytology GABAergic Neuroglia Calretinin Gabapentin medicine.drug Cell Adhesion Molecules Neuronal 610 Medicine & health Nerve Tissue Proteins Axons/metabolism Biology gamma-Aminobutyric acid Article Extracellular Matrix Proteins/metabolism Nerve Net/metabolism Serine Endopeptidases/metabolism Cell Lineage/genetics Receptors GABA Interneurons medicine Animals Pyramidal Cells/metabolism Cell Lineage 10242 Brain Research Institute Axons Rats Reelin Protein nervous system Forebrain Receptors GABA/metabolism biology.protein 570 Life sciences biology Interneurons/metabolism Nerve Net Neuroscience Parvalbumin |
| Zdroj: | Europe PubMed Central Fuentealba, P, Klausberger, T, Karayannis, T, Suen, W Y, Huck, J, Tomioka, R, Rockland, K, Capogna, M, Studer, M, Morales, M & Somogyi, P 2010, ' Expression of COUP-TFII nuclear receptor in restricted GABAergic neuronal populations in the adult rat hippocampus ', The Journal of neuroscience : the official journal of the Society for Neuroscience, vol. 30, no. 5, pp. 1595-609 . https://doi.org/10.1523/JNEUROSCI.4199-09.2010 |
| ISSN: | 1529-2401 |
| DOI: | 10.1523/JNEUROSCI.4199-09.2010 |
| Popis: | The COUP-TFII nuclear receptor, also known as NR2F2, is expressed in the developing ventral telencephalon and modulates the tangential migration of a set of subpallial neuronal progenitors during forebrain development. Little information is available about its expression patterns in the adult brain. We have identified the cell populations expressing COUP-TFII and the contribution of some of them to network activityin vivo. Expression of COUP-TFII by hippocampal pyramidal and dentate granule cells, as well as neurons in the neocortex, formed a gradient increasing from undetectable in the dorsal to very strong in the ventral sectors. In the dorsal hippocampal CA1 area, COUP-TFII was restricted to GABAergic interneurons and expressed in several, largely nonoverlapping neuronal populations. Immunoreactivity was present in calretinin-, neuronal nitric oxide synthase-, and reelin-expressing cells, as well as in subsets of cholecystokinin- or calbindin-expressing or radiatum-retrohippocampally projecting GABAergic cells, but not in parvalbumin- and/or somatostatin-expressing interneurons.In vivorecording and juxtacellular labeling of COUP-TFII-expressing cells revealed neurogliaform cells, basket cells in stratum radiatum and tachykinin-expressing radiatum dentate innervating interneurons, identified by their axodendritic distributions. They showed cell type-selective phase-locked firing to the theta rhythm but no activation during sharp wave/ripple oscillations. These basket cells in stratum radiatum and neurogliaform cells fired at the peak of theta oscillations detected extracellularly in stratum pyramidale, unlike previously reported ivy cells, which fired at the trough. The characterization of COUP-TFII-expressing neurons suggests that this developmentally important transcription factor plays cell type-specific role(s) in the adult hippocampus. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|