Association of polymorphisms in endothelial dysfunction-related genes with susceptibility to essential hypertension in elderly Han population in Liaoning province, China
| Autor: | Fanxin Zeng, Yuetian Yang, Mengke Shang, Lanxin Ou, Xiaotong Wang, Mengwei Liu, Yue Wang, Zhibin Yang, Man Liang, Fangfang Nie, Wanyang Liu, Na Ta, Xiuping Liu, Lu Wen |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
Vascular Endothelial Growth Factor A medicine.medical_specialty vascular endothelial dysfunction Genome-wide association study Single-nucleotide polymorphism Cell Cycle Proteins Essential hypertension Polymorphism Single Nucleotide polymorphism Internal medicine Genetic model Genotype medicine Humans Diseases of the circulatory (Cardiovascular) system Genetic Predisposition to Disease Endothelial dysfunction Allele Adaptor Proteins Signal Transducing Aged business.industry essential hypertension Nuclear Proteins General Medicine medicine.disease Vascular endothelial growth factor A Endocrinology Case-Control Studies RC666-701 Hypertension Cardiology and Cardiovascular Medicine business Genome-Wide Association Study |
| Zdroj: | Reviews in Cardiovascular Medicine, Vol 22, Iss 3, Pp 895-901 (2021) |
| ISSN: | 2153-8174 |
| Popis: | Hypertension is a complex disease which is mainly influenced by genetic factors. Recently, genome-wide association study (GWAS) found three novel endothelial dysfunction-related sites: Vascular endothelial growth factor A (VEGFA) rs9472135, Faciogenital dysplasia 5 (FGD5) rs11128722, Zinc Finger C3HC-type Containing 1 (ZC3HC1) rs11556924. Endothelial dysfunction is one of the early events in pathophysiology of essential hypertension. To investigate the association of endothelial dysfunction-related genes with essential hypertension, we conducted a case-control study of 431 patients with hypertension and 345 controls. The polymorphisms were detected using Taqman Probe. The alleles and genotypes of ZC3HC1 rs11556924 and VEGFA rs9472135 were not statistically different between the two groups, while the allele of FGD5 rs11128722 was different [P = 0.045, OR = 1.265, 95% CI = (1.009–1.586)], especially in the male [P = 0.035, OR = 1.496, 95% CI = (1.037–2.158)]. Analyzing the different of genotype distribution of 3 SNPs in the two groups under different genetic models, the genotypes of FGD5 rs11128722 showed difference in male under dominant model [P = 0.049, OR = 1.610, 95% CI = (1.018–2.544)]. The polymorphism of FGD5 rs11128722 had a significant difference in Body Mass Index (BMI) among different genotypes; In the additive genetic model, BMI of GA genotype was higher than that of GG (P = 0.038); GA + AA was higher than GG in the dominant genetic model (P = 0.011). In our study, we found that the polymorphisms of VEGFA rs9472135 and ZC3HC1 rs11556924 may not significantly associated with the risk of essential hypertension, and FGD5 rs11128722 may increase the risk of it, especially in elderly men. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|