Study of nasopharyngeal bacterial flora. Variations in nasopharyngeal bacterial flora in schoolchildren and adults when administered antimicrobial agents
| Autor: | Yoshitaka Okamoto, Toshimitsu Kobayashi, Shunkichi Baba, M. Furukawa, Kohei Hara, Tadao Nishimura, Kimitaka Kaga, Nobuhiko Furuya, Hiroshi Moriyama, Fumio Matsumoto, Toshiharu Matsushima, Haruki Mikawa, Shigeru Kohno, Yasuyuki Yoshizawa, Noboru Yamanaka, Masatoshi Konno, Kimiko Ubukata, Kunihiko Kobayashi, Matsuhisa Inoue, Keisuke Sunakawa, Shoichi Koizumi, Akihiro Morikawa |
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| Rok vydání: | 2007 |
| Předmět: |
Adult
Male Microbiology (medical) medicine.medical_specialty Adolescent Drug resistance medicine.disease_cause law.invention Haemophilus influenzae Microbiology Moraxella catarrhalis Medical microbiology Japan law Drug Resistance Multiple Bacterial Nasopharynx Streptococcus pneumoniae medicine Humans Pharmacology (medical) Child Sinusitis Respiratory Tract Infections Aged Aged 80 and over biology Age Factors Middle Aged medicine.disease Antimicrobial biology.organism_classification Anti-Bacterial Agents Otitis Media Treatment Outcome Infectious Diseases Gram staining Immunology Female |
| Zdroj: | Journal of Infection and Chemotherapy. 13:235-254 |
| ISSN: | 1341-321X |
| DOI: | 10.1007/s10156-007-0533-8 |
| Popis: | Changes in nasopharyngeal bacterial flora in adults with acute upper respiratory tract infection on administration of antimicrobial agents were investigated, and how these changes contrasted with those in children. Many patients with acute sinusitis due to allergies, and patients with malignancy and diabetes mellitus were included in the investigation. The detection rates of Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis, the major bacteria of acute otitis media (AOM), were 22%, 10%, and 7% respectively, which were significantly lower than those for children. Gram stain examination of nasopharyngeal swab samples showed a significant relation between leukocyte infiltration and the detection amount of S. pneumoniae (P = 0.0086). A significant relation (P = 0.0134) was also observed when H. influenzae was simultaneously detected. No significant change in the three major AOM bacteria present in nasopharyngeal bacterial flora after administration of antimicrobial agents was observed. However, all S. pneumoniae and H. influenzae detected after antimicrobial agent administration had the beta-lactam-resistance gene. It was observed that a significant improvement in leukocyte infiltration occurred 6 to 10 days after antimicrobial agent administration. In contrast, a significant improvement in children was observed at 2 to 5 days. In the adult subjects, this improvement was probably due to spontaneous remission rather than the effect of the antimicrobial agents. Although investigation of the long-term administration of antimicrobial agents was also conducted, its benefits for the patients were not elucidated. |
| Databáze: | OpenAIRE |
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