Fulminant ecchymosis as the initial manifestation of antiphospholipid syndrome (APS) triggered by respiratory syncytial virus (RSV) infection: A case report and review of the literature
| Autor: | Sanjana C. Koshy, Sonal Bajaj, David C. Perlman, Young-Gwang Jeong, Jun Makino |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Software_OPERATINGSYSTEMS Fulminant Ecchymosis Context (language use) Case Report Infectious and parasitic diseases RC109-216 030204 cardiovascular system & hematology medicine.disease_cause Virus 03 medical and health sciences 0302 clinical medicine Antiphospholipid syndrome medicine Past medical history Anticardiolipin antibodies (aCL) business.industry ComputerSystemsOrganization_COMPUTER-COMMUNICATIONNETWORKS respiratory system medicine.disease ComputingMilieux_MANAGEMENTOFCOMPUTINGANDINFORMATIONSYSTEMS 030104 developmental biology Infectious Diseases Respiratory syncytial virus (RSV) Immunology Antiphospholipid syndrome (APS) medicine.symptom Differential diagnosis business MathematicsofComputing_DISCRETEMATHEMATICS |
| Zdroj: | IDCases IDCases, Vol 7, Iss C, Pp 19-22 (2017) |
| ISSN: | 2214-2509 |
| DOI: | 10.1016/j.idcr.2016.10.013 |
| Popis: | Highlights • Various infections have been associated with APS. • This is a first case report an association with RSV infection and APS. We present a unique and informative instance of respiratory syncytial virus (RSV) infection associated with antiphospholipid syndrome (APS), and discuss this case in the context of the literature addressing the immunopathogenesis of APS associated with diverse infections. We describe the case of a 43-year-old man with no significant past medical history who presented with the acute onset of fever, hemoptysis, and extensive bullous, ecchymotic lesions in both lower extremities. Punch biopsy of the lesion demonstrated thrombotic vasculopathy. Further evaluation revealed serum antiphospholipid antibodies as well as a positive RSV PCR in a nasal swab specimen. Clinical manifestations, positive laboratory and pathological findings were strongly suggestive of APS associated with a recent RSV infection. When an infectious etiology is considered for APS, RSV should also be included in the differential diagnosis. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|