The extent to which childhood adversity and recent stress influence all-cause mortality risk in older adults

Autor: Karen Ritchie, Jade Johnson, Jacqueline Scali, Marie-Laure Ancelin, Isabelle Chaudieu, Joanne Ryan
Přispěvatelé: Monash University [Melbourne], Neuropsychiatrie : recherche épidémiologique et clinique (PSNREC), Université Montpellier 1 (UM1)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), University of Edinburgh, CCSD, Accord Elsevier, Université Montpellier 1 (UM1)-Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM), Pathologies du système nerveux : recherche épidémiologique et clinique, Université Montpellier 1 (UM1)-IFR76-Institut National de la Santé et de la Recherche Médicale (INSERM), Neuropsychiatrie : recherche épidémiologique et clinique
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Male
Endocrinology
Diabetes and Metabolism
[SDV]Life Sciences [q-bio]
Poison control
Stress
Suicide prevention
Occupational safety and health
Life Change Events
03 medical and health sciences
0302 clinical medicine
Endocrinology
Sex Factors
Adverse Childhood Experiences
Risk Factors
Surveys and Questionnaires
Injury prevention
Medicine
Humans
Child Abuse
Risk factor
Mortality
Adverse effect
Child
Biological Psychiatry
ComputingMilieux_MISCELLANEOUS
Aged
Proportional Hazards Models
Retrospective Studies
Aged
80 and over
Endocrine and Autonomic Systems
business.industry
Proportional hazards model
Gender-specific
Human factors and ergonomics
Early-life adversities
030227 psychiatry
3. Good health
[SDV] Life Sciences [q-bio]
Psychiatry and Mental health
Child
Preschool
Female
Independent Living
business
030217 neurology & neurosurgery
Stress
Psychological
Demography
Zdroj: Psychoneuroendocrinology
Psychoneuroendocrinology, Elsevier, 2020, 111, pp.104492. ⟨10.1016/j.psyneuen.2019.104492⟩
ISSN: 0306-4530
DOI: 10.1016/j.psyneuen.2019.104492⟩
Popis: Background Psychological stress is recognized as a major risk factor for a range of non-communicable diseases and possibly mortality. The extent to which the type and timing of stress exposure influences mortality, and potential differences between genders, remains unknown. Objective To examine the association between early-life and recent stressful experiences and mortality risk in later life, and to determine possible gender differences in these associations. Method Data were obtained from 2152 French community-dwelling participants (aged ≥65). Questionnaires were used to evaluate recent stress, as well as retrospective reporting of childhood adversity. Mortality status was determined through death registries. Adjusted Cox proportional hazards models were used to determine the association between stress and 16-year mortality risk. Results Over a mean 12.9 years, 850 people died. Having a childhood home environment with very serious conflicts was associated with a 54% increased mortality risk (95%CI:1.21-1.96), and childhood abuse/maltreatment with a 34% increased risk (95% CI:1.05-1.70). For females, specific childhood events (serious illness HR:1.91, 95%CI:1.40–2.60; war/natural disaster HR:1.47, 95%CI:1.14-1.88) and the number of events (≥5 adverse events HR:1.91, 95%CI:1.25-2.32), also increased mortality risk. In terms of recent events, mortality risk increased by 66% (95%CI:1.39-2.00) in participants reporting a recent serious illness or physical trauma and by 86% for those reporting problems with the police/justice (95%CI:1.05-3.30). Among males specifically, mortality risk also increased with major financial problems (HR:1.92, 95%CI:1.14-3.21), and when they had a relative with a serious illness (HR:1.26, 95%CI:1.01–1.55). Conclusions Stressful life experiences are associated with all-cause mortality however the associations varied between early-life adversities and recent stress, and were different across the genders. Among females, certain types of childhood adversity continue to predict mortality risk in later life, while in males specific recent stress significantly increased mortality risk.
Databáze: OpenAIRE
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