Recognition ability and cytotoxicity of some oligosaccharidylsubstituted β-cyclodextrins
| Autor: | Roger Bonaly, Fatima Attioui, Chantal Finance, Hélène Parrot-Lopez, Eric Leray, Anouar Al-Omar |
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| Rok vydání: | 1994 |
| Předmět: |
Cell Survival
Molecular Sequence Data Oligosaccharides Saccharomyces cerevisiae Biology Article Kluyveromyces chemistry.chemical_compound Tumor Cells Cultured medicine Animals Humans cell recognition Cytotoxicity Cyclodextrins beta-Cyclodextrins Lectin Biological activity Flocculation Tests Hemagglutination Tests Cell Biology General Medicine medicine.disease Hemolysis Yeast sugar substituted Red blood cell Eukaryotic Cells Membrane medicine.anatomical_structure Carbohydrate Sequence chemistry Biochemistry Galactose biology.protein lectin cytotoxicity β-cyclodextrins |
| Zdroj: | Biology of the Cell |
| ISSN: | 0248-4900 |
| DOI: | 10.1016/s0248-4900(94)80018-9 |
| Popis: | This paper reports a chemico-enzymatic synthesis of beta-CD derivatives. The recognition properties of these derivatives were tested using flocculating yeast and isolated lectins. It was observed that the substitution of beta-cyclodextrins with galactose end arms induces the better recognition by a cell-linked galactose-specific lectin. The physicochemical effects of the beta-CD derivatives on membranes were estimated using red blood cells and the effects on the viability of yeast and human rectal tumor cells were appreciated by measuring the mitochondrial deshydrogenase activity. The substitutions of the beta-CD ring by sugar antennae decrease the negative physicochemical effects of the beta-CD, ie their hemolytic properties. However, these substitutions induce significant modifications of the biological properties of the molecules, particularly the cytotoxicity and the growth of eukaryotic cells. |
| Databáze: | OpenAIRE |
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