Interaction of cyclosporine with phenobarbital in cats: a preliminary study
| Autor: | Riko Otaka, Daisuke Fukui, Takanori Inden, Masaaki Katayama, Yuki Hoshino, Hiroshi Satoh |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Blood level
Male 040301 veterinary sciences cat Administration Oral Biological Availability phenobarbital Pharmacology Multiple dosing 0403 veterinary science 03 medical and health sciences Pharmacokinetics Oral administration medicine Animals Drug Interactions 030304 developmental biology First pass 0303 health sciences CATS General Veterinary Dose-Response Relationship Drug business.industry 04 agricultural and veterinary sciences Note Bioavailability Cats Cyclosporine Phenobarbital business pharmacokinetics Immunosuppressive Agents medicine.drug |
| Zdroj: | The Journal of Veterinary Medical Science |
| ISSN: | 1347-7439 0916-7250 |
| Popis: | Phenobarbital (PB) decreases the cyclosporine (CsA) blood level in humans. However, the interaction of PB with CsA has not been reported in cats. This study investigated the effects of multiple doses of PB on the pharmacokinetics of CsA in three healthy cats. The treatments included oral CsA 5 mg/kg alone and oral CsA 5 mg/kg plus PB 5 mg/kg for 4 weeks. Co-administration of PB with CsA resulted in significant decreases in the oral bioavailability of CsA though both the first pass and elimination phases. These preliminary results suggest that oral administration of multiple doses of PB increases the required CsA dosage in CsA-based immunosuppressive therapy in cats. |
| Databáze: | OpenAIRE |
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