Acute rheumatic fever: 10-year single-center experience: clinical and laboratory findings, with subclinical carditis and treatment complications
| Autor: | Ali Bülbül, Canan Hasbal Akkuş, Gizem Kara Elitok, Mehmet Bedir Akyol, Lida Bulbul, Sami Hatipoğlu, Hasret Ayyildiz Civan |
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| Rok vydání: | 2021 |
| Předmět: |
Toxic hepatitis
Inotrope Male medicine.medical_specialty Arthritis Single Center Internal medicine Statistical significance Medicine Humans Child Subclinical infection business.industry Medical record Rheumatic Heart Disease Carditis General Medicine medicine.disease Myocarditis Echocardiography Pediatrics Perinatology and Child Health Female medicine.symptom Rheumatic Fever Cardiology and Cardiovascular Medicine business Laboratories |
| Zdroj: | Cardiology in the young. 31(9) |
| ISSN: | 1467-1107 1047-9511 |
| Popis: | Background:Acute rheumatic fever in childhood continues to cause serious morbidity despite all developments. The objective of this study was to evaluate the clinical and laboratory characteristics of patients with acute rheumatic fever and to determine the frequency of subclinical carditis and the side effects of the drugs used in the treatment.Methods:The data of patients hospitalised between 2008 and 2018 with the diagnosis of acute rheumatic fever were included in the study. The relationship of gender and age with the frequency of major symptoms and the distribution of the drugs used in the treatment and their side effects were evaluated.Results:Medical records of 102 patients with complete data were reviewed. 56.9% of the patients were male and the mean age was 10.7 ± 1.9 years. The most common distribution of complaints found were arthritis (51%), arthralgia (25.5%) and fever (16.7%). 10.8% of all patients (n = 11) were diagnosed subclinical carditis via echocardiographic evaluation. The frequency of carditis was higher in female patients with a borderline statistical significance (p = 0.05). However, there was no statistically significant difference between gender and arthritis (p = 0.22) and carditis (p > 0.05). Anti-congestive therapy was required in 22% and inotropic treatment was needed in 6.1% cases. Toxic hepatitis developed in four cases during the acetylsalicylic acid treatment.Conclusions:In a 10-year period, detection of subclinical carditis in 10.8% cases supported that echocardiography should be performed as a standard method for the diagnosis of acute rheumatic fever. Patients should be followed closely in terms of hepatic toxicity due to acetylsalicylic acid used in the treatment. |
| Databáze: | OpenAIRE |
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