Interferon-alpha 2b combined with daily ketoprofen administration improves virological response in chronic hepatitis C: a prospective and randomised trial
| Autor: | Munne Ms, Diego Martin Flichman, Podestá A, Terg R, Levi D, Alberto Muñoz, Cabanne A, Maria Bartellini, Gorín Jm, González J |
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| Rok vydání: | 2000 |
| Předmět: |
Ketoprofen
Male medicine.medical_specialty medicine.medical_treatment Alpha interferon Interferon alpha-2 Gastroenterology Antiviral Agents Article Drug Administration Schedule Interferon Internal medicine medicine Humans Prospective Studies Adverse effect Interferon alfa Chemotherapy business.industry Anti-Inflammatory Agents Non-Steroidal Interferon-alpha Hepatitis C Hepatitis C Chronic Middle Aged medicine.disease Recombinant Proteins Surgery Chronic Disease Commentary Drug Therapy Combination Female Viral hepatitis business medicine.drug |
| Zdroj: | Gut. 46(3) |
| ISSN: | 0017-5749 |
| Popis: | BACKGROUND—Less than 15% of patients with chronic hepatitis C show a sustained virological response to interferon treatment. AIM—To evaluate the efficacy and safety of different doses of ketoprofen combined with interferon-α 2b in the treatment of chronic hepatitis C. PATIENTS/METHODS—Seventy compensated patients with chronic hepatitis C received interferon-α 2b 3 million units three times a week for six months. They were randomly assigned to: group 1 (n = 23), interferon-α 2b alone; group 2 (n = 23), interferon-α 2b plus 200 mg ketoprofen three times a week; group 3 (n = 24), interferon-α 2b plus 200 mg ketoprofen twice a day. Complete and sustained responses were defined as normal serum alanine aminotransferase levels and negative serum hepatitis C virus RNA at six and 12 months respectively. RESULTS—Complete and sustained responses were similar in groups 1 and 2: 10% v 5% and 5% v 0% respectively. In group 3, complete response was 29% (p = 0.13 v group 1 and p = 0.04 v group 2) and sustained response was 26% (p = 0.07 v group 1 and p = 0.01 v group 2). Overall, adverse events were similar in the three groups. However, 'flu-like syndrome was less common in group 2 (30%) and group 3 (37%) than in group 1 (77%) (p = 0.01). CONCLUSIONS—Twice daily ketoprofen administration combined with interferon-α 2b produced an increase in complete and sustained responses. Although the combination of interferon-α 2b with ketoprofen was well tolerated and decreased the incidence of 'flu-like syndrome, it is advisable to monitor possible non-steroid anti-inflammatory drug hepatotoxicity. Keywords: interferon-α; ketoprofen; non-steroid anti-inflammatory drugs; prostaglandins; viral hepatitis; hepatitis C |
| Databáze: | OpenAIRE |
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