mi-R4435-2HG promotes proliferation and inhibits apoptosis of cancer cells in ovarian carcinoma by upregulating ROCK2
| Autor: | Jinghui Hu, Wei Zhao, Zhe Wang, Heping Shen, Li Wang, Yujie Huang |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Cancer Research Gene knockdown Oncogene Chemistry proliferation Cancer Articles Cell cycle medicine.disease Rho-associated protein kinase 2 ovarian carcinoma 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Oncology Downregulation and upregulation Apoptosis 030220 oncology & carcinogenesis Ovarian carcinoma long noncoding RNA mi-R4435-2HG Cancer cell medicine Cancer research inhibited apoptosis |
| Zdroj: | Oncology Letters |
| ISSN: | 1792-1082 1792-1074 |
| Popis: | The present study aimed to investigate the involvement of long noncoding RNA mi-R4435-2HG in ovarian carcinoma. mi-R4435-2HG and Rho-associated protein kinase 2 (ROCK2) were demonstrated to both be upregulated in ovarian carcinoma. mi-R4435-2HG and ROCK2 were positively correlated in both tumor and healthy tissues. mi-R4435-2HG overexpression mediated the upregulation of ROCK2, while upregulation of ROCK2 did not affect mi-R4435-2HG. Overexpression of mi-R4435-2HG and ROCK2 led to promoted proliferation and inhibited apoptosis of cancer cells, while mi-R4435-2HG and ROCK2 knockdown had the opposite effect. In addition, ROCK2 knockdown attenuated the effects of mi-R4435-2HG overexpression on cancer cell proliferation and apoptosis. Therefore, mi-R4435-2HG promotes proliferation and inhibits apoptosis of cancer cells in ovarian carcinoma by upregulating ROCK2. |
| Databáze: | OpenAIRE |
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