Author Correction: Genome-wide association study of depression phenotypes in UK Biobank identifies variants in excitatory synaptic pathways
| Autor: | Howard, David M., Adams, Mark J., Shirali, Masoud, Clarke, Toni Kim, Marioni, Riccardo E., Davies, Gail, Coleman, Jonathan R.I., Alloza, Clara, Shen, Xueyi, Barbu, Miruna C., Wigmore, Eleanor M., Gibson, Jude, Agee, Michelle, Alipanahi, Babak, Auton, Adam, Bell, Robert K., Bryc, Katarzyna, Elson, Sarah L., Fontanillas, Pierre, Furlotte, Nicholas A., Hinds, David A., Huber, Karen E., Kleinman, Aaron, Litterman, Nadia K., McCreight, Jennifer C., McIntyre, Matthew H., Mountain, Joanna L., Noblin, Elizabeth S., Northover, Carrie A.M., Pitts, Steven J., Sathirapongsasuti, J. Fah, Sazonova, Olga V., Shelton, Janie F., Shringarpure, Suyash, Tian, Chao, Tung, Joyce Y., Vacic, Vladimir, Wilson, Catherine H., Hagenaars, Saskia P., Lewis, Cathryn M., Ward, Joey, Smith, Daniel J., Sullivan, Patrick F., Haley, Chris S., Breen, Gerome, Deary, Ian J., McIntosh, Andrew M. |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Science
MEDLINE General Physics and Astronomy Genome-wide association study Nerve Tissue Proteins Computational biology Biology Mechanotransduction Cellular Synaptic Transmission General Biochemistry Genetics and Molecular Biology Linkage Disequilibrium Cohort Studies International Classification of Diseases Humans Genetic Predisposition to Disease Author Correction Depression (differential diagnoses) Biological Specimen Banks Depressive Disorder Major Multidisciplinary Depression General Chemistry Biobank Phenotype United Kingdom Gene Expression Regulation Genetic Loci Synapses Excitatory postsynaptic potential Biomarkers Genome-Wide Association Study |
| Zdroj: | Howard, D M, Adams, M J, Shirali, M, Clarke, T K, Marioni, R E, Davies, G, Coleman, J R I, Alloza, C, Shen, X, Barbu, M C, Wigmore, E M, Gibson, J, Agee, M, Alipanahi, B, Auton, A, Bell, R K, Bryc, K, Elson, S L, Fontanillas, P, Furlotte, N A, Hinds, D A, Huber, K E, Kleinman, A, Litterman, N K, McCreight, J C, McIntyre, M H, Mountain, J L, Noblin, E S, Northover, C A M, Pitts, S J, Sathirapongsasuti, J F, Sazonova, O V, Shelton, J F, Shringarpure, S, Tian, C, Tung, J Y, Vacic, V, Wilson, C H, Hagenaars, S P, Lewis, C M, Ward, J, Smith, D J, Sullivan, P F, Haley, C S, Breen, G, Deary, I J & McIntosh, A M 2021, ' Author Correction: Genome-wide association study of depression phenotypes in UK Biobank identifies variants in excitatory synaptic pathways ', Nature Communications, vol. 12, 2012 . https://doi.org/10.1038/s41467-021-22411-w Nature Communications, Vol 12, Iss 1, Pp 1-1 (2021) Nature Communications |
| Popis: | Depression is a polygenic trait that causes extensive periods of disability. Previous genetic studies have identified common risk variants which have progressively increased in number with increasing sample sizes of the respective studies. Here, we conduct a genome-wide association study in 322,580 UK Biobank participants for three depression-related phenotypes: broad depression, probable major depressive disorder (MDD), and International Classification of Diseases (ICD, version 9 or 10)-coded MDD. We identify 17 independent loci that are significantly associated (P 5 × 10 |
| Databáze: | OpenAIRE |
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