Factors influencing survival after pancreatoduodenectomy for ductal adenocarcinoma depend on patients' age
| Autor: | Kestutis Urbonas, Giedrius Barauskas, Juozas Pundzius, Aldona Jakstaite, Giedrė Smailyte, Darius Pranys, Antanas Gulbinas |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Oncology
Adult Aged 80 and over Male medicine.medical_specialty business.industry Incidence (epidemiology) Gastroenterology Age Factors Middle Aged Survival Analysis Pancreaticoduodenectomy Pancreatic Neoplasms Risk Factors Internal medicine medicine Humans Surgery Female Ductal adenocarcinoma business Aged Carcinoma Pancreatic Ductal |
| Zdroj: | Digestive surgery. 32(1) |
| ISSN: | 1421-9883 |
| Popis: | Background: It is supposed that a prolonged lifetime will be associated with increased incidence of PDAC among the elderly. Some studies show a tendency toward decreased survival in the elderly patients following pancreatoduodenectomy for PDAC. The aim of this study was to evaluate factors, influencing survival following pancreatoduodenectomy for PDAC in different age groups. Methods: Data of 251 patients after pancreatoduodenectomy for PDAC between 1999 and 2012 were analyzed. The Kaplan-Meier method and log-rank test were used to calculate survival and to compare differences between groups. The Cox proportional hazard model was applied to indentify independent prognosticators. Results: The overall median survival was 14.9 months. Postoperative morbidity was 25.5% with a 5.1% mortality rate. No significant differences in the overall morbidity (22.4 vs. 29.6%) or mortality (2.8 vs. 8.3%) rates were observed between different patients' age groups (70 years). Multivariate analysis revealed R1 resection (HR 1.76) and poor tumor differentiation (G3-G4) (HR 1.48) were independent negative factors for survival in patients Conclusions: Our study highlighted different factors influencing long-term survival after pancreatoduodenectomy: R1 resection and poor tumor differentiation (G3-G4) were independent negative factors for survival in patients |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|