Cannabinoids negatively modulate striatal glutamate and dopamine release and behavioural output of acute d-amphetamine
| Autor: | G. Naxakis, Zeta Papadopoulou-Daifoti, Alexia Polissidis, Katerina Antoniou, D. Papahatjis, Olga Chouliara, Andreas Galanopoulos |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Male
Dopamine Microdialysis Morpholines medicine.medical_treatment Glutamic Acid Motor Activity Naphthalenes Pharmacology Synaptic Transmission Rats Sprague-Dawley Behavioral Neuroscience chemistry.chemical_compound Neurochemical Piperidines Receptor Cannabinoid CB1 medicine Animals Neurotransmitter Amphetamine Cannabinoid Receptor Antagonists Cannabinoids Dopaminergic Glutamate receptor Endocannabinoid system Corpus Striatum Benzoxazines Rats chemistry Pyrazoles Central Nervous System Stimulants Drug Therapy Combination Cannabinoid Rimonabant Neuroscience medicine.drug |
| Zdroj: | Behavioural Brain Research. 270:261-269 |
| ISSN: | 0166-4328 |
| DOI: | 10.1016/j.bbr.2014.05.029 |
| Popis: | The cannabinoid system plays a regulatory role in neurotransmission and is involved in the central actions of psychostimulants. This complex interaction between the cannabinoid system and psychostimulants represents a potential pharmacological target for psychosis and addiction. However, most studies have focused on cocaine, therefore, it is unclear whether these findings can be extended to other psychostimulants such as the amphetamines. The present study investigated the effects of WIN55,212-2, a synthetic cannabinoid and SR141716A, a CB1 receptor antagonist, on d -amphetamine-induced locomotor activity and extracellular dopamine and glutamate release in the striatum. Rats were either observed for locomotor activity or glutamate and dopamine neurotransmitter release in the striatum using in vivo microdialysis following intraperitoneal co-administration of d -amphetamine with WIN55,212-2 or SR141716A. Our results demonstrated that d -amphetamine per se induced hyperlocomotion and enhanced dopamine and glutamate release, as expected. WIN55,212-2 dampened these effects when co-administered with d -amphetamine, while alone it displayed its characteristic biphasic motor profile coupled with increases in dopamine and decreases in glutamate release. SR141716A at high doses reduced d -amphetamine-induced hyperlocomotion and completely reversed enhanced dopamine and glutamate release but alone had no effect. These findings validate the capacity of the cannabinoid system to modulate amphetamine-induced behaviour and its neurochemical output, in a state-dependent manner, providing insight into aspects of the neurobiological substrate that underlies amphetamines’ psychotogenic and addictive properties. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect