Diffusion Tensor Imaging in Parkinson's Disease and Parkinsonian Syndrome: A Systematic Review
| Autor: | Marc A. Burock, Yu Zhang |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Parkinson's disease (PD) Parkinson's disease Review diffusion tensor imaging (DTI) fractional anisotropy (FA) Parkinson's progression marker initiative (PPMI) lcsh:RC346-429 White matter 03 medical and health sciences 0302 clinical medicine diffusion tensor tractography (DTT) Fractional anisotropy Medicine dopaminergic pathway substantia nigra (SN) lcsh:Neurology. Diseases of the nervous system business.industry Neurodegeneration Correction Diagnostic marker medicine.disease Parkinsion's disease (PD) 030104 developmental biology medicine.anatomical_structure Neurology Research strategies Dopaminergic pathways Neurology (clinical) business Neuroscience 030217 neurology & neurosurgery Diffusion MRI |
| Zdroj: | Frontiers in Neurology, Vol 11 (2020) Frontiers in Neurology |
| ISSN: | 1664-2295 |
| DOI: | 10.3389/fneur.2020.531993/full |
| Popis: | Diffusion tensor imaging (DTI) allows measuring fractional anisotropy and similar microstructural indices of the brain white matter. Lower than normal fractional anisotropy as well as higher than normal diffusivity is associated with loss of microstructural integrity and neurodegeneration. Previous DTI studies in Parkinson's disease (PD) have demonstrated abnormal fractional anisotropy in multiple white matter regions, particularly in the dopaminergic nuclei and dopaminergic pathways. However, DTI is not considered a diagnostic marker for the earliest Parkinson's disease since anisotropic alterations present a temporally divergent pattern during the earliest Parkinson's course. This article reviews a majority of clinically employed DTI studies in PD, and it aims to prove the utilities of DTI as a marker of diagnosing PD, correlating clinical symptomatology, tracking disease progression, and treatment effects. To address the challenge of DTI being a diagnostic marker for early PD, this article also provides a comparison of the results from a longitudinal, early stage, multicenter clinical cohort of Parkinson's research with previous publications. This review provides evidences of DTI as a promising marker for monitoring PD progression and classifying atypical PD types, and it also interprets the possible pathophysiologic processes under the complex pattern of fractional anisotropic changes in the first few years of PD. Recent technical advantages, limitations, and further research strategies of clinical DTI in PD are additionally discussed. |
| Databáze: | OpenAIRE |
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