Teratogenic effects of pantothenic acid deficiency in the rat
| Autor: | Marjorie M. Nelson, Herbert M. Evans, Howard V. Wright, Catherine D. C. Baird |
|---|---|
| Rok vydání: | 1957 |
| Předmět: |
Vitamin
medicine.medical_specialty Fetus Nutrition and Dietetics Offspring Retinol Medicine (miscellaneous) Biology Pyridoxine Pantothenic Acid Congenital Abnormalities Rats chemistry.chemical_compound Endocrinology chemistry Vitamin B Deficiency Internal medicine Pantothenic acid medicine Animals Vitamin B12 Cyanocobalamin medicine.drug |
| Zdroj: | The Journal of nutrition. 62(3) |
| ISSN: | 0022-3166 |
| Popis: | Nelson and Evans ('46) demonstrated that pantothenic acid deficiency in the rat resulted in fetal death with rA©sorp tion or in undersized young, some of which were stillborn. Since then, Lefebvres-Boisselot ('51) has observed a high incidence of cerebral and eye defects, digital hemorrhages and edema in rat fetuses from pantothenic acid-deficient mothers. Zunin and Borrone ( '54) have reported the occurrence of similar anomalies in the offspring of pregnant rats given pantothenic acid-deficient diets containing the antimetabolite, pantoyltaurine. These reports have prompted our reinvestigation of the effects of pantothenic acid deficiency on embryonic development in the rat. The effects of the vitamin antimet abolite, omega-methyl-pantothenic acid, have also been studied. |
| Databáze: | OpenAIRE |
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