Adiponectin and resistin in PCOS: a clinical, biochemical and molecular genetic study

G and 276 G-->T polymorphisms in the adiponectin gene, and the -420 C-->G variant in the resistin gene, were analysed. Results Serum adiponectin concentrations were reduced in PCOS patients compared with controls (P = 0.038) irrespective of the degree of obesity, whereas serum resistin levels were increased in overweight and obese women compared with lean subjects (P = 0.016), irrespective of their PCOS or controls status. The adiponectin and resistin polymorphisms were not associated with PCOS and did not influence serum levels of adiponectin, resistin and other clinical and hormonal variables. In a multiple regression model, the waist-to-hip ratio, free testosterone levels and age, but not insulin resistance, were the major determinants of hypoadiponectinaemia. Conclusions PCOS patients present with hypoadiponectinaemia, in relation with abdominal adiposity and hyperandrogenism. Our present results suggest that hyperandrogenism and abdominal obesity, by reducing the serum levels of the insulin sensitizer adipokine adiponectin, might contribute to the insulin resistance of PCOS. -->

ISSN:	1460-2350 0268-1161
DOI:	10.1093/humrep/del146
Přístupová URL adresa:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55db37f7ee4cf51f88498b41eda53707 https://doi.org/10.1093/humrep/del146
Rights:	OPEN
Přírůstkové číslo:	edsair.doi.dedup.....55db37f7ee4cf51f88498b41eda53707
Autor:	Manuel Luque-Ramírez, José I. Botella-Carretero, Francisco Álvarez-Blasco, Héctor F. Escobar-Morreale, Gemma Villuendas, J. L. San Millán, Raul Sanchón
Rok vydání:	2006
Předmět:	Adult medicine.medical_specialty Genotype endocrine system diseases medicine.medical_treatment Adipokine Blood Pressure Biology Insulin resistance Internal medicine medicine Humans Resistin Obesity Abdominal obesity Polymorphism Genetic Adiponectin Insulin Rehabilitation Hyperandrogenism nutritional and metabolic diseases Obstetrics and Gynecology medicine.disease Polycystic ovary Cross-Sectional Studies Endocrinology Reproductive Medicine Case-Control Studies Female Insulin Resistance medicine.symptom hormones hormone substitutes and hormone antagonists Polycystic Ovary Syndrome
Zdroj:	Human Reproduction. 21:2257-2265
ISSN:	1460-2350 0268-1161
DOI:	10.1093/humrep/del146
Popis:	Background We conducted a cross-sectional case-control study to evaluate the possible involvement of adiponectin and resistin in the pathogenesis of polycystic ovary syndrome (PCOS). Methods Seventy-six PCOS patients and 40 non-hyperandrogenic women matched for BMI and degree of obesity were included. Serum adiponectin and resistin levels, anthropometrical and hormonal variables, the 45 T-->G and 276 G-->T polymorphisms in the adiponectin gene, and the -420 C-->G variant in the resistin gene, were analysed. Results Serum adiponectin concentrations were reduced in PCOS patients compared with controls (P = 0.038) irrespective of the degree of obesity, whereas serum resistin levels were increased in overweight and obese women compared with lean subjects (P = 0.016), irrespective of their PCOS or controls status. The adiponectin and resistin polymorphisms were not associated with PCOS and did not influence serum levels of adiponectin, resistin and other clinical and hormonal variables. In a multiple regression model, the waist-to-hip ratio, free testosterone levels and age, but not insulin resistance, were the major determinants of hypoadiponectinaemia. Conclusions PCOS patients present with hypoadiponectinaemia, in relation with abdominal adiposity and hyperandrogenism. Our present results suggest that hyperandrogenism and abdominal obesity, by reducing the serum levels of the insulin sensitizer adipokine adiponectin, might contribute to the insulin resistance of PCOS.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55db37f7ee4cf51f88498b41eda53707 https://doi.org/10.1093/humrep/del146 Zobrazit plný text záznamu