Design, synthesis and anti-tumor activity of novel benzothiophenonaphthalimide derivatives targeting mitochondrial DNA (mtDNA) G-quadruplex

Autor:	Qiong Huang, Xiao Wang, An Chen, Hua Zhang, Qimeng Yu, Chenfeng Shen, Annoor Awadasseid, Xiaoyin Zhao, Xuqiong Xiong, Yanling Wu, Wen Zhang
Rok vydání:	2022
Předmět:	Pharmacology Molecular Structure Antineoplastic Agents Apoptosis Biochemistry DNA Mitochondrial Mitochondria Mice Naphthalimides Structure-Activity Relationship Cell Line Tumor Animals Humans Drug Screening Assays Antitumor Cell Proliferation
Zdroj:	Biochemical pharmacology. 201
ISSN:	1873-2968
Popis:	A series of new naphthalimide derivatives, benzothiophenonaphthalimides (7a-7g, 8a-8g), were designed and synthesized, of which compounds 8a-8g are hydrochloride salts of corresponding compounds 7a-7g. All compounds presented different anti-tumor activities for tumor cells tested by the CCK-8 assay. In particular, compound 7c displayed the strongest anti-tumor activity with an IC
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55dad004e82c0cc449a4079245db0068 https://pubmed.ncbi.nlm.nih.gov/35504316 Zobrazit plný text záznamu Full Text from ScienceDirect