Tissue-Specific Accumulation and Antioxidant Defenses in Flounder (Paralichthys olivaceus) Juveniles Experimentally Exposed to Methylmercury
| Autor: | Dayan Zhou, Liang Cao, Zhonghua Ren, Wenting Cui, Shuozeng Dou, Zhenbo Lv, Jinhu Liu |
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| Rok vydání: | 2020 |
| Předmět: |
Gill
Gills medicine.medical_specialty Antioxidant 010504 meteorology & atmospheric sciences Health Toxicology and Mutagenesis medicine.medical_treatment Flounder 010501 environmental sciences Toxicology medicine.disease_cause 01 natural sciences Antioxidants Superoxide dismutase Lipid peroxidation chemistry.chemical_compound Internal medicine medicine Animals 0105 earth and related environmental sciences Glutathione Transferase Glutathione Peroxidase biology Chemistry Superoxide Dismutase Fishes General Medicine Glutathione Mercury Methylmercury Compounds biology.organism_classification Pollution Oxidative Stress Endocrinology Liver Catalase biology.protein Lipid Peroxidation Oxidative stress Biomarkers Water Pollutants Chemical |
| Zdroj: | Archives of environmental contamination and toxicology. 79(4) |
| ISSN: | 1432-0703 |
| Popis: | Methylmercury (MeHg) is the most toxic form of mercury and can accumulate in the cells of marine organisms, such as fish, causing adverse effects on various physiological functions. This study examined MeHg accumulation and its toxicological role in antioxidant defenses in tissues, including the liver, gills, and muscle of flounder (Paralichthys olivaceus) juveniles. After 30 d of MeHg exposure (0, 0.1, 1.0, 10.0, and 20.0 µg L−1), the accumulation of MeHg in the three tissues correlated positively with the concentration of MeHg and exhibited tissue specificity in the order of liver > gills > muscle. Among the antioxidant markers, the activities of SOD (superoxide dismutase) and GST (glutathione S-transferase) as well as the content of glutathione (GSH) in the liver and gills were induced at 0.1–10.0 µg L−1 but repressed at 20.0 µg L−1. The activities of SOD and GST and the content of GSH in the muscle significantly increased with increasing MeHg concentration. Catalase (CAT) activity in the liver was induced at 0.1–1.0 µg L−1 but inhibited at 10.0–20.0 µg L−1, whereas exposure to MeHg did not remarkably affect CAT activity in the gills and muscle. The levels of lipid peroxidation (LPO) increased dose dependently, showing tissue specificity with the highest level in the liver, then the gills, followed by muscles. Overall, higher sensitivity to oxidative stress induced by MeHg was detected in the liver than the gills and muscle. These findings improve our understanding of the tissue-specific accumulation of heavy metals and their roles in antioxidant responses in marine fish subjected to MeHg exposure. |
| Databáze: | OpenAIRE |
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