Oxidative Stress Markers and Their Dynamic Changes in Patients after Acute Ischemic Stroke

Autor: Maria Chomova, Ingrid Žitňanová, Branislav Kollár, Katarína Koňariková, Zuzana Krivošíková, Petra Pazderová, Lucia Andrezálová, Lucia Laubertová, Miriam Ježovičová, Pavol Šiarnik, Peter Turcani, Laura Slezáková
Jazyk: angličtina
Rok vydání: 2016
Předmět:
0301 basic medicine
Male
Aging
Antioxidant
medicine.medical_treatment
medicine.disease_cause
Biochemistry
Antioxidants
chemistry.chemical_compound
0302 clinical medicine
Stroke
chemistry.chemical_classification
Aged
80 and over
biology
Chemistry
lcsh:Cytology
Glutathione peroxidase
General Medicine
Middle Aged
Catalase
Female
Research Article
medicine.medical_specialty
Lipid Peroxides
Article Subject
Superoxide dismutase
03 medical and health sciences
Internal medicine
medicine
Humans
lcsh:QH573-671
Free-radical theory of aging
Aged
Glutathione Peroxidase
Aryldialkylphosphatase
Superoxide Dismutase
Cholesterol
HDL
Cell Biology
Glutathione
Cholesterol
LDL
medicine.disease
Surgery
Oxidative Stress
030104 developmental biology
Endocrinology
Case-Control Studies
biology.protein
030217 neurology & neurosurgery
Oxidative stress
Biomarkers
Follow-Up Studies
Zdroj: Oxidative Medicine and Cellular Longevity
Oxidative Medicine and Cellular Longevity, Vol 2016 (2016)
ISSN: 1942-0994
1942-0900
Popis: We have focused on determining the range of oxidative stress biomarkers and their dynamic changes in patients at different time points after the acute ischemic stroke (AIS). 82 patients with AIS were involved in our study and were tested: within 24 h from the onset of the attack (group A); at 7-day follow-up (group B); and at 3-month follow-up (group C). 81 gender and age matched volunteers were used as controls. Stroke patients in group A had significantly higher concentrations of plasma lipid peroxides and urine 8-isoprostanes when compared with controls. Protein carbonyls were not significantly different in any experimental group compared to controls. Antioxidant capacity of plasma was increased only in experimental group C. Activities of superoxide dismutase and catalase were elevated in all three experimental AIS groups compared to controls. Paraoxonase activity was reduced in groups A and B and unchanged in group C when compared to controls. Glutathione peroxide activity was elevated only in group A. Our results suggest that free radical damage is the highest within 24 h after the attack. During the next 3 months oxidative damage to lipids caused by free radicals is reduced due to activated antioxidant system.
Databáze: OpenAIRE
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