A Programmable Multi-biomarker Neural Sensor for Closed-loop DBS
| Autor: | Jaclyn Beckinghausen, Abbas Z. Kouzani, Roy V. Sillitoe, Tao Lin, Mahboubeh Parastarfeizabadi |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
neural sensor General Computer Science Preamplifier Computer science Digital potentiometer Flash memory Article 03 medical and health sciences 0302 clinical medicine Circuits Limit (music) General Materials Science Digital electronics closed-loop business.industry General Engineering Feedback loop Microcontroller 030104 developmental biology multiple biomarkers lcsh:Electrical engineering. Electronics. Nuclear engineering business Closed loop lcsh:TK1-9971 030217 neurology & neurosurgery Computer hardware programmable |
| Zdroj: | IEEE Access, Vol 7, Pp 230-244 (2019) |
| ISSN: | 2169-3536 |
| Popis: | Most of the current closed-loop deep brain stimulation (DBS) devices use a single biomarker in their feedback loop, which may limit their performance and applications. This paper presents the design, fabrication, and validation of a programmable multi-biomarker neural sensor which can be integrated into closed-loop DBS devices. The device is capable of sensing a combination of low-frequency (7–45 Hz), and high-frequency (200–1000 Hz) neural signals. The signals can be amplified with a digitally programmable gain within the range of 50–100 dB. The neural signals can be stored into a local memory for processing and validation. The sensing and storage functions are implemented via a combination of analog and digital circuits involving pre-amplifiers, filters, programmable post-amplifiers, microcontroller, digital potentiometer, and flash memory. The device is fabricated, and its performance is validated through: 1) bench tests using sinusoidal and pre-recorded neural signals; 2) in-vitro tests using pre-recorded neural signals in saline solution; and 3) in-vivo tests by recording neural signals from freely moving laboratory mice. The animals were implanted with a PlasticsOne electrode, and recording was conducted after recovery from the electrode implantation surgery. The experimental results are presented and discussed confirming the successful operation of the device. The size and weight of the device enable tetherless back-mountable use in pre-clinical trials. |
| Databáze: | OpenAIRE |
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