Multi-organ pathological findings associated with COVID-19 in postmortem needle core biopsies in four patients and a review of the current literature
| Autor: | Sagrario García Sánchez, Silvia Salinas Moreno, María del Mar Lorido Cortés, Marta Muñoz Fernández de Legaria, Margarita Elices Apellániz, Tais González Pessolani |
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| Rok vydání: | 2021 |
| Předmět: |
Male
medicine.medical_specialty Pathology Histopathology Spleen Pathogenesis Disease 030204 cardiovascular system & hematology Pathology and Forensic Medicine 03 medical and health sciences 0302 clinical medicine Microscopía Neumonía medicine Humans Pathological Aged Lung business.industry Brief Report COVID-19 Patología Pneumonia Middle Aged medicine.disease Coronavirus Patogénesis medicine.anatomical_structure 030220 oncology & carcinogenesis Immunohistochemistry Autopsy Biopsy Large-Core Needle business |
| Zdroj: | Revista Espanola De Patologia Revista Española de Patología |
| ISSN: | 1699-8855 |
| DOI: | 10.1016/j.patol.2020.09.003 |
| Popis: | Coronavirus disease 2019 (COVID-19) has spread worldwide, resulting in significant morbidity and mortality. Histopathological findings are essential in understanding its pathogenesis and we present our findings from postmortem core needle biopsies in an attempt to share information that may shed some light on this severe pandemic. Different organ samples from four patients with PCR-confirmed COVID-19 at the Infanta Sofía Hospital (Madrid) were studied during the months of April and May, 2020 by six pathologists using routine stains, histochemistry and immunohistochemistry. Results were compared with other reported cases. All patients had a clinical diagnosis of pneumonia and biopsies revealed lung damage in the majority. Heart, liver, spleen and kidney were also studied and abnormalities were found in all cases and are extensively described. The histopathology of organs affected by COVID-19 is vital to the understanding of this disease and its sequelae. |
| Databáze: | OpenAIRE |
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