Immunohistochemical Expression of COX-2 in Thyroid Nodules
| Autor: | Yeo Joo Kim, Kyo Il Suh, Ji Sung Yoon, Ji O Mok, Sang Jin Kim, Myung Hi Yoo, Hyeong Kyu Park, Dongwon Byun, Jae-Hak Lee, Chul Hee Kim |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2003 |
| Předmět: |
Thyroid nodules
Pathology medicine.medical_specialty endocrine system endocrine system diseases medicine.disease_cause Malignancy Thyroiditis medicine Biomarkers Tumor Humans Anaplastic carcinoma Thyroid Nodule business.industry Thyroid Membrane Proteins Hyperplasia COX-2 medicine.disease Immunohistochemistry Isoenzymes medicine.anatomical_structure Cyclooxygenase 2 Prostaglandin-Endoperoxide Synthases Original Article Carcinogenesis business |
| Zdroj: | The Korean Journal of Internal Medicine |
| ISSN: | 2005-6648 1226-3303 |
| Popis: | Background: Recent evidence indicates that elevated COX-2 expression is associated with the carcinogenesis of numerous neoplasms. In this study, we investigated COX-2 expression in various thyroid specimens in order to elucidate its physiological role in pathologic conditions, and to evaluate the efficiency of COX-2 protein expression as a molecular marker of malignancy in the thyroid gland. Methods: COX-2 expression was studied immunohistochemically in 19 papillary carcinomas, 8 follicular carcinomas, 14 follicular adenomas, 2 Hurthle cell carcinomas, 4 Hurthle cell adenomas, 8 nodular hyperplasias, 3 Graves' diseases, 3 Hashimoto's thyroiditis, 2 medullary carcinomas, 1 anaplastic carcinoma, and 20 normal thyroid tissues. Results: COX-2 staining was not seen in any of the normal thyroid, Graves' disease, or nodular hyperplasia specimens. In contrast, COX-2 staining was observed in all of papillary carcinomas, Hashimoto's thyroiditis, Hurthle cell carcinomas, and Hurthle cell adenomas tissues. Moreover, 7 of 8 follicular carcinomas and 11 of 14 follicular adenomas showed COX-2 staining. Conclusion: These results indicate that COX-2 is not useful as a marker of malignancy. Since COX-2 expression was evident in follicular adenomas and in papillary and follicular carcinomas. Thus, the enzyme may be involved in the early process of thyroid tumorigenesis. |
| Databáze: | OpenAIRE |
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