Asymmetric synthesis of tetrahydrolipstatin and valilactone

Autor:	Paul M. Roberts, James E. Thomson, Stephen C. Case-Green, Angela J. Russell, Stephen G. Davies
Jazyk:	angličtina
Rok vydání:	2016
Předmět:	Inorganic Chemistry Chiral auxiliary chemistry.chemical_compound chemistry Tandem Aldol reaction Valilactone Stereochemistry Organic Chemistry Enantioselective synthesis Noyori asymmetric hydrogenation Physical and Theoretical Chemistry Catalysis
Popis:	The highly diastereoselective aldol reaction between acyl complexes of the iron chiral auxiliary [(η 5-C 5H 5)Fe(CO)(PPh 3)] and β-hydroxy aldehydes (obtained via a Noyori asymmetric hydrogenation), followed by a tandem oxidative decomplexation-cyclisation process gives access to β-substituted and α,β-disubstituted β-lactones in high ee. This methodology has been employed in the asymmetric syntheses of tetrahydrolipstatin and valilactone. © 2008 Elsevier Ltd. All rights reserved.
Databáze:	OpenAIRE
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