Study The Anticancer Effect Of Curcumin, Paraquat And Brusatol Combinations Against The Pulmonary Carcinoma (Nci-H292) (Atcc ® Crl-1848™)
| Autor: | Dilla Jose, P. Senthilkumaar |
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| Rok vydání: | 2018 |
| Předmět: | |
| DOI: | 10.5281/zenodo.1210251 |
| Popis: | The present study scrutinized the anticancer activity of curcumin, paraquat and brusatol combinations against the pulmonary carcinoma (NCI-H292) (ATCC® CRL-1848™) by two different methods such as colony forming and apoptosis assay. Significant increase in colony formation compared to the control was observable in 25 µg/ml dose of curcumin. In colony forming assay at both concentration study (50 and 100 µg/ml), high increase in colony formation resulted in 50 µg/ml dose of curcumin. Likewise in apoptosis study, high increase in apoptosis resulted in 50 µg/ml dose of curcumin. This study is witnessed that combination of these things were support the anticancer activity in large extend. {"references":["1.\tAggarwal, B.B., Anushree Kumar, Manoj S. Aggarwal and Shishir Shishodia. (2005) Curcumin Derived from Turmeric (Curcuma longa): a Spice for All Seasons. CRC Press LLC, 340-380. 2.\tChan, W.H., Chih-Ching Wu and Jau-Song Yu. (2003) Curcumin Inhibits UV Irradiation-Induced Oxidative Stress and Apoptotic Biochemical Changes in Human Epidermoid Carcinoma A431 Cells. Journal of Cellular Biochemistry, 90: 327–338. 3.\tHuang, H.C., C.L. Lin and J.K. Lin. (2011) 1,2,3,4,6-penta-O-galloyl-β-D-glucose, quercetin, curcumin and lycopene induce cell-cycle arrest in MDA-MB-231 and BT474 cells through down regulation of Skp2 protein. J. Agric. Food Chem., 22; 59(12): 6765-6775. 4.\tJia, T., Li Zhang, Yale Duan, Min Zhang, Gang Wang, Jun Zhang and Zheng Zhao. (2014) The differential susceptibilities of MCF-7 and MDA-MB-231 cells to the cytotoxic effects of curcumin are associated with the PI3K/Akt-SKP2-Cip/Kips pathway. Cancer Cell International, 14:126. 5.\tJiang, M., Ou Huang, Xi Zhang, Zuoquan Xie, Aijun Shen, Hongchun Liu, Meiyu Geng and Kunwei Shen. (2013) Curcumin Induces Cell Death and Restores Tamoxifen Sensitivity in the Antiestrogen-Resistant Breast Cancer CellLines MCF-7/LCC2 and MCF-7/LCC9. Molecules, 18: 701-720. 6.\tLin, J.K. (2007) Molecular targets of curcumin. Adv. Exp. Med. Biol., 595: 227-243."]} |
| Databáze: | OpenAIRE |
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