Nuclear texture analysis: a new prognostic tool in metastatic prostate cancer

Autor: Kjell J. Tveter, Trond Jørgensen, Fredrik Skjørten, Håvard E. Danielsen, Kanagasingam Yogesan
Rok vydání: 1996
Předmět:
Zdroj: Cytometry. 24(3)
ISSN: 0196-4763
Popis: This report describes the prognostic due of computerized nuclear texture analysis in metastatic prostate cancer. Seventy-seven patients with histologically verified prostate carcinomas and skeletal metastases were selected from a Scandinavian multicenter study (SPCG-2). Thirty-sh therapy-resistant patients experienced objective progression and cancer-related death within 2 years after orchiectomy. Thirty patients responded well to orchiectomy, i.e., showed objective dkase remission and no signs of progression during 3 years of follow-up. From this data set, 10 randomly chosen therapy-resistant and 10 randomly chosen therapy-sensitive carcinomas were used in our previous study to find the optimal combination of features that can discriminate between the two groups (Yogesan et al.: Cytometry 24:268-276, 1996). In addition to these two groups, 11 patients experienced stable disease or disease remission during the fhst year and a secondary progression during the second or third year of follow-up, with subsequent cancer-related death. Traditional clinical prognostic factors such as histoProstate cancer is the most common malignancy among men in Western world. The incidence is increasing, due mainly to the fact that the average age of the male population in the West has been climbing steadily for many years and to the increased awareness of this disease (9). Numerous questions remain unanswered concerning prostate cancer, and the biological behavior of the carcinomas is unpredictable. When the diagnosis is established, the majority of patients do not show organ- confined disease (33). Prostate cancer cells usually depend on androgens for proliferation, as do normal prostate cells. Elimination of testosterone by surgical or medical castration is the fust line of palliative treatment of advanced stages of prostate cancer. Approximately 70% of the carcinomas respond to endocrine treatment, but disease regression is temporary. The carcinoma probably becomes hormone resistant due to proliferation of androgen-independent cancer cells, which more and more will pathological grading and serum markers could not discriminate between these groups of patients. Therefore, image analysis techniques based on texture analysis have been utilized in this study of prognosis of prostate cancer. Feulgen-stained monolayers of nuclei were prepared from parafhembedded material taken from the primary tumor before endocrine ablation. Four different textural features were selected from the training data set to calculate the discriminating function. This function separated the therapy-sensitive and the therapy-resistant patients with 87% accuracy in the independent data set. This study demonstrates that it is possible to predict tumor progression and survival for endocrine-ablated metastatic prostate carcinomas using computerized nuclear texture analysis on light microscopy images from prostate biopsies taken at the time of diagnosis. o 1996 wiky-~iss, hc.
Databáze: OpenAIRE
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