A vascular smooth muscles nitric oxide relaxation by a mechanism distinct of calcium changes
| Autor: | Mireille Danna, Fabienne Chabaud, Jean-Louis Bény |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Fura-2
Swine Muscle Relaxation Indomethacin Bradykinin chemistry.chemical_element Vasodilation In Vitro Techniques Substance P Calcium Arginine Dinoprost Nitric Oxide Nitroarginine Muscle Smooth Vascular General Biochemistry Genetics and Molecular Biology Calcium in biology Nitric oxide Nitroglycerin chemistry.chemical_compound Cytosol Isometric Contraction Animals General Pharmacology Toxicology and Pharmaceutics Egtazic Acid Calcimycin Calcium metabolism Ionomycin General Medicine Anatomy Coronary Vessels Acetylcholine Spectrometry Fluorescence chemistry Potassium Biophysics Endothelium Vascular |
| Zdroj: | Life Sciences. 54:1449-1458 |
| ISSN: | 0024-3205 |
| DOI: | 10.1016/0024-3205(94)00600-8 |
| Popis: | Prostaglandin F2 alpha contracts coronary arteries smooth muscles under conditions of extra cellular and intracellular calcium depletion. In these conditions, nitrogen-oxide-containing vasodilators or natural EDRF(s) released by the kinins, substance P and bradykinin, from the endothelium relax strips of pig coronary arteries. This indicates that nitric oxide not only needs to lower cytosolic free calcium to relaxes the smooth muscles, but in addition another mechanism, independent of cytosolic calcium changes, is necessary to fully relax strips contracted by Prostaglandin F2 alpha. |
| Databáze: | OpenAIRE |
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