Simvastatin improves hematopoietic stem cell engraftment by preventing irradiation-induced marrow adipogenesis and radio-protecting the niche cells
| Autor: | Vaijayanti Kale, Suprita S. Ghode, Lalita Limaye, Rohan S. Kulkarni, Manmohan S. Bajaj |
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| Rok vydání: | 2015 |
| Předmět: |
Simvastatin
Adipogenesis Transplantation Conditioning business.industry Graft Survival Niche Hematopoietic Stem Cell Transplantation Hematopoietic stem cell Radiation-Protective Agents Hematology Hematopoietic Stem Cells Therapeutic targeting Mice medicine.anatomical_structure Bone Marrow Cancer research Animals Medicine Bone marrow Stem Cell Niche Online Only Articles business medicine.drug |
| Zdroj: | Haematologica. |
| ISSN: | 1592-8721 0390-6078 |
| DOI: | 10.3324/haematol.2015.124750 |
| Popis: | Pre-transplant myeloablation increases bone marrow (BM) adipogenesis and destroys the niche cells, adversely affecting the hematopoietic stem cell (HSC) engraftment. This becomes a serious issue when donor HSCs are few or if their functionality is compromised. Therapeutic targeting of the niche[1][1 |
| Databáze: | OpenAIRE |
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