Recombination does not generate pinworm susceptibility during experimental crosses between two mouse subspecies
| Autor: | Jean-Marc Derothe, Claude Loubes, Adeline Porcherie, Catherine Moulia, Marco Perriat-Sanguinet |
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| Rok vydání: | 2004 |
| Předmět: |
Male
Heterosis Animals Wild Subspecies Biology Genome Mice Hybrid zone Species Specificity Hybrid Vigor Animals Genetic Predisposition to Disease Crosses Genetic Hybrid Recombination Genetic Genetics Sex Characteristics General Veterinary Enterobiasis General Medicine Immunity Innate Infectious Diseases Aspiculuris tetraptera Insect Science Hybridization Genetic Female Parasitology Disease Susceptibility Enterobius Recombination |
| Zdroj: | Parasitology Research. 93 |
| ISSN: | 1432-1955 0932-0113 |
| Popis: | The susceptibility to Aspiculuris tetraptera of European Mus musculus hybrids is thought to reflect the disruption of genomic co-adaptation through recombination of the parental genomes. Here, we compared the susceptibility to this parasite between parents and experimental hybrids (intersubspecific until F4, intrasubspecific F1, F2) to clarify the contributions of heterosis and subspecies incompatibility. F1 showed hybrid vigor. Unlike intrasubspecific F2, intersubspecific F2 were less resistant than F1, but revealed no increased susceptibility relative to the parents. Intersubspecific F3 and F4 showed the same hybrid vigor as F1. Heterosis contributed most to the resistance, but the differences between intra- and intersubspecific F2 suggested genomic incompatibilities between subspecies. However, the susceptibility did not increase through the recombination process, showing that disruption of co-adaptation does not directly affect resistance. Even if previous studies still support the selective role of parasites in the current hybrid zone, an alternative hypothesis on the origin of hybrid susceptibility is warranted. |
| Databáze: | OpenAIRE |
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