Quantitative Assessment the Relationship between p21 rs1059234 Polymorphism and Cancer Risk
Autor: | Yongsheng Huang, Lin Wang, Qianqian Fan, Meng Nie, Hongyang Quan, Chuang Li |
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Rok vydání: | 2015 |
Předmět: |
Cyclin-Dependent Kinase Inhibitor p21
Oncology Cancer Research medicine.medical_specialty Epidemiology Cell growth Kinase Public Health Environmental and Occupational Health Biology Bioinformatics Polymorphism Single Nucleotide Stratified analysis Head and Neck Neoplasms Risk Factors Neoplasms Internal medicine Carcinoma Squamous Cell Quantitative assessment medicine Humans Basal cell Dominant model Head and neck Cancer risk |
Zdroj: | Asian Pacific Journal of Cancer Prevention. 16:4435-4438 |
ISSN: | 1513-7368 |
Popis: | p21 is a cyclin-dependent kinase inhibitor, which can arrest cell proliferation and serve as a tumor suppressor. Though many studies were published to assess the relationship between p21 rs1059234 polymorphism and various cancer risks, there was no definite conclusion on this association. To derive a more precise quantitative assessment of the relationship, a large scale meta-analysis of 5,963 cases and 8,405 controls from 16 eligible published case–control studies was performed. Our analysis suggested that rs1059234 was not associated with the integral cancer risk for both dominant model [(T/T+C/T) vs C/C, OR=1.00, 95% CI: 0.84-1.18] and recessive model [T/T vs (C/C+C/T), OR=1.03, 95% CI: 0.93-1.15)]. However, further stratified analysis showed rs1059234 was greatly associated with the risk of squamous cell carcinoma of head and neck (SCCHN). Thus, larger scale primary studies are still required to further evaluate the interaction of p21 rs1059234 polymorphism and cancer risk in specific cancer subtypes. |
Databáze: | OpenAIRE |
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