Serum creatine kinase levels after a single intramuscular injection--dependence on injection volume
| Autor: | Zaher S. Azzam, O Zinder, N Krivoy, G Alroy |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Adult
Male 030213 general clinical medicine medicine.medical_specialty Paraldehyde Clinical Biochemistry 030209 endocrinology & metabolism Injections Intramuscular 03 medical and health sciences 0302 clinical medicine Diabetes mellitus Internal medicine Papaverine medicine Humans Myocardial infarction Creatine Kinase Aged Aged 80 and over biology Dose-Response Relationship Drug business.industry Skeletal muscle General Medicine Hydralazine Middle Aged medicine.disease medicine.anatomical_structure Endocrinology Methotrexate biology.protein Haloperidol Creatine kinase Female Intramuscular injection business Rhabdomyolysis Diazepam medicine.drug |
| Zdroj: | Annals of clinical biochemistry. 31 |
| ISSN: | 0004-5632 |
| Popis: | Creatine kinase (CK) is an important marker in the diagnosis of acute myocardial infarction (AMI). There are, however, other clinical conditions other than AMI which cause elevation of total CK activities in serum including: skeletal muscle trauma; alcohol intoxication; uncontrolled diabetes mellitus; convulsions; pulmonary emboli; rhabdomyolysis; and many others. I•2 An increase in serum levels of CK has been demonstrated following administration of a wide variety of drugs." However, there is as yet no unifying hypothesis regarding the mechanism of this phenomenon. Steiness et al," have shown that certain medications such as diazepam cause an increase in serum CK activity as a result of muscle damage. The amount of CK liberated is determined both by the properties of the solution injected (active compound, vehicle, concentration, and volume) and by muscle factors such as local muscle blood flow, susceptibility of muscle to the damaging effect of the injection and local muscle binding to the medication. However, the common clinical notion regarding intramuscular (1M) injections as a frequent cause of serum CK elevations leading to an erroneous diagnosis of AMI in patients who have been given an 1M injection for non-cardiac reasons has been challenged by Konicoff et al.s We investigated serum CK elevation following a single 1M injection of medications commonly used in patients admitted to a medical ward. |
| Databáze: | OpenAIRE |
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