Effect of bridging ligand structure on the thermal stability and DNA binding properties of iron(ii) triple helicates
| Autor: | Isabelle Meistermann, Mirela Pascu, Per Lincoln, Michael J. Hannon, Guy J. Clarkson, Yolanda Parajo, Alison Rodger, Jaroslav Malina |
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| Rok vydání: | 2009 |
| Předmět: |
Models
Molecular Circular dichroism Stereochemistry Imine Crystallography X-Ray Ligands Linear dichroism Binding Competitive Inorganic Chemistry chemistry.chemical_compound Cations Ethidium Animals Molecule Ferrous Compounds Molecular Structure Oligonucleotide Hydrogen bond Circular Dichroism Temperature Bridging ligand DNA Crystallography chemistry Nucleic Acid Conformation Cattle Spectrophotometry Ultraviolet Imines |
| Zdroj: | Dalton Transactions. :4868 |
| ISSN: | 1477-9234 1477-9226 |
| DOI: | 10.1039/b822039e |
| Popis: | Triple helical di-iron complexes, readily prepared through interaction of iron(II) ions with imine-based ligands, are cylinder-shaped tetracations comparable in size and shape to common protein DNA recognition units. They have a strong tendency to coil DNA, and have recently been found to induce formation of three-way junctions in palindromic oligonucleotides. To introduce potential H bond acceptor units onto the surface of triple-helicates, new iron(II) complexes have been synthesized in which the central linking unit in the bridging ligand is S or O, instead of CH(2). The DNA binding properties of these new metallo-helicates were studied using UV-vis spectroscopy and circular and linear dichroism. Results show that the three iron triple helicates bind the DNA in a similar way but that the stability of the triple helicate unit is decreased with the O linked bridging ligand. |
| Databáze: | OpenAIRE |
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