Epidemiology of infections and antimicrobial use in Greek Neonatal Units
| Autor: | Despoina, Gkentzi, Christina, Kortsalioudaki, Benjamin Campbell, Cailes, Theoklis, Zaoutis, John, Kopsidas, Maria, Tsolia, Nikos, Spyridis, Soultana, Siahanidou, Kosmas, Sarafidis, Paul T, Heath, Gabriel, Dimitriou, Aikaterini, Avgeri |
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| Rok vydání: | 2018 |
| Předmět: |
Male
medicine.medical_specialty medicine.drug_class Antibiotics Psychological intervention Gestational Age Microbial Sensitivity Tests Sepsis 03 medical and health sciences 0302 clinical medicine Anti-Infective Agents Intensive Care Units Neonatal 030225 pediatrics Internal medicine Drug Resistance Bacterial Epidemiology Humans Antimicrobial stewardship Medicine 030212 general & internal medicine Practice Patterns Physicians' Retrospective Studies Cross Infection Greece Neonatal sepsis business.industry Incidence Incidence (epidemiology) Infant Newborn Obstetrics and Gynecology General Medicine medicine.disease Antimicrobial Drug Utilization Pediatrics Perinatology and Child Health Drug Therapy Combination Female Neonatal Sepsis business |
| Zdroj: | Archives of Disease in Childhood - Fetal and Neonatal Edition. 104:F293-F297 |
| ISSN: | 1468-2052 1359-2998 |
| DOI: | 10.1136/archdischild-2018-315024 |
| Popis: | ObjectiveTo describe the epidemiology of neonatal infections and of antimicrobial use in Greek Neonatal Units (NNUs) in order to develop national, evidence-based guidelines on empiric antimicrobial use for neonatal sepsis in Greece.DesignRetrospective analysis of prospectively collected infection surveillance data from 2012 to 2015, together with a Point Prevalence Survey (PPS) on antimicrobial use and the collection of data on local empiric antimicrobial policies.Setting16 NNUs in Greece participating in the neonIN infection surveillance networkPatientsNewborns in participating NNUs who had a positive blood, cerebrospinal fluid or urine culture and were treated with at least 5 days of antibiotics.Results459 episodes were recorded in 418 infants. The overall incidence of infection was 50/1000 NNU-admissions. The majority of episodes were late-onset sepsis (LOS) (413, 90%).Coagulase-negative Staphylococci(80%) were the most common Gram-positive organisms causing LOS andKlebsiellaspp (39%) the most common Gram-negative. Nearly half (45%) of theKlebsiellaspp were resistant to at least one aminoglycoside. The PPS revealed that 196 of 484 (40%) neonates were on antimicrobials. The survey revealed wide variation in empiric antimicrobial policies for LOS.ConclusionsThis is the largest collection of data on the epidemiology of neonatal infections in Greece and on neonatal antimicrobial use. It provides the background for the development of national evidence-based guidelines. Continuous surveillance, the introduction of antimicrobial stewardship interventions and evidence-based guidelines are urgently required. |
| Databáze: | OpenAIRE |
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