Oil from the marine zooplankton Calanus finmarchicus improves the cardiometabolic phenotype of diet-induced obese mice
| Autor: | Ahmed M. Khalid, Terje S. Larsen, Jan Raa, Wahida Salma, Anne D. Hafstad, Anje Christina Höper, Selene J. Sollie, Ellen Aasum |
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| Rok vydání: | 2013 |
| Předmět: |
Male
medicine.medical_specialty Calanus finmarchicus Abdominal Fat Medicine (miscellaneous) Adipose tissue Mice Obese Biology Diet High-Fat Weight Gain Antioxidants Zooplankton Copepoda chemistry.chemical_compound Mice Insulin resistance Internal medicine Adipocyte Fatty Acids Omega-3 Glucose Intolerance medicine Animals Obesity RNA Messenger Abdominal obesity Biological Products Nutrition and Dietetics Adiponectin Ecology Macrophages medicine.disease biology.organism_classification Fatty Liver Mice Inbred C57BL Endocrinology chemistry Adipose Tissue Cardiovascular Diseases Dietary Supplements Cytokines Steatosis medicine.symptom Diet-induced obese |
| Zdroj: | The British journal of nutrition. 110(12) |
| ISSN: | 1475-2662 |
| Popis: | The aim of the present study was to investigate the effects of oil extracted from the zooplanktonCalanus finmarchicus(Calanus oil) on diet-induced obesity and obesity-related disorders in mice. C57BL/6J mice fed a high-fat diet (HFD, 45 % energy from fat) exhibited increased body weight and abdominal fat accumulation as well as impaired glucose tolerance compared with mice fed a normal chow diet (10 % energy from fat). Supplementing the HFD with 1·5 % (w/w) Calanus oil reduced body-weight gain, abdominal fat accumulation and hepatic steatosis by 16, 27 and 41 %, respectively, and improved glucose tolerance by 16 %. Calanus oil supplementation reduced adipocyte size and increased the mRNA expression of adiponectin in adipose tissue. It also reduced macrophage infiltration by more than 70 %, accompanied by reduced mRNA expression of pro-inflammatory cytokines (TNF-α, IL-6 and monocyte chemotactic protein-1). The effects of Calanus oil were not only preventive, but also therapeutic, as the oil proved to be beneficial, regardless of whether the supplementation was started before or after the onset of obesity and glucose intolerance. Although the present study cannot pinpoint the active component(s) of the oil, there is reason to believe that then-3 fatty acids EPA and DHA and/or antioxidants are responsible for its beneficial effects. It should be noted that the concentration ofn-3 fatty acids in the Calanus oil diet was considerably lower than the concentrations used in similar studies reporting beneficial effects on obesity and obesity-related abnormalities. |
| Databáze: | OpenAIRE |
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