Familial-Related Risks for Congenital Hypothyroidism in Iranian Newborns: A Population-Based Case-Control Study
| Autor: | Mahmood Salesi, Nasrin Azhang, Khaled Rahmani, Shahin Yarahmadi |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Endocrinology Diabetes and Metabolism Population 030209 endocrinology & metabolism 03 medical and health sciences 0302 clinical medicine 030225 pediatrics medicine Congenital Hypothyroidism Population Attributable Fraction education education.field_of_study Pregnancy Intra-family Marriage Obstetrics business.industry Case-control study Odds ratio medicine.disease Newborn Screening Program Confidence interval Congenital hypothyroidism Gestational diabetes Attributable risk Familial Risk Factor business Research Article |
| Zdroj: | International Journal of Endocrinology and Metabolism |
| ISSN: | 1726-9148 1726-913X |
| Popis: | Background: Congenital hypothyroidism (CH), as one of the most common endocrine disorders, is a preventable cause of mental retardation. Objective: This study aimed to identify familial-related risk factors for CH in Iranian newborns. Methods: A population-based case-control study was performed on the National Registry System of patients with CH in Iran. In this study, 906 controls and 454 cases were studied for one year. Familial related factors were investigated using logistic regression models. Population attributable fraction (PAF) was also calculated for each significant risk factor. Results: Using multivariate analysis, an increased risk for CH was observed in patients with congenital anomalies (odds ratio (OR): 5.77, 95% confidence interval (CI): 2.37 - 14.01), history of mental retardation in family (OR:2.10, 95% CI: 1.15-3.83), mother’s hypothyroidism during pregnancy (OR: 2.01, 95% CI: 1.33 - 3.03), intra-family marriage (OR:1.49, 95% CI: 1.18 - 1.89), gestational diabetes (OR: 1.69, 95% CI: 1.09 - 2.63), having a hypothyroid child in the family (OR: 2.48, 95% CI: 1.39 - 4.42), and twins or more (OR: 2.61, 95% CI: 1.31 - 5.21). The highest PAF among familial-related risk factors for CH is related to the intra-family marriage (14.9%). Conclusions: This study revealed that familial-related risk factors and consanguine marriages play an essential role in the high incidence of CH in Iran. About 15% of CH in Iran could be attributed to intra-family marriage alone. |
| Databáze: | OpenAIRE |
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