Serum levels of matrix metalloproteinase 9 and toll-like receptor 4 in acute aortic dissection: a case-control study

Autor: Jun Yang, Shi-Jie Xin, Jingjing Jing, Tan Li, Yuehua Gong, Liping Sun, Yuan Yuan
Rok vydání: 2018
Předmět:
Adult
Male
medicine.medical_specialty
lcsh:Diseases of the circulatory (Cardiovascular) system
Matrix metalloproteinase 9
Enzyme-Linked Immunosorbent Assay
030204 cardiovascular system & hematology
Gastroenterology
Fibrin Fibrinogen Degradation Products
03 medical and health sciences
Aortic aneurysm
0302 clinical medicine
Predictive Value of Tests
Internal medicine
Medicine
Humans
Acute aortic dissection
Angiology
Aged
Aortic dissection
Inflammation
biology
business.industry
C-reactive protein
Case-control study
Middle Aged
medicine.disease
Toll-like receptor 4
Pathophysiology
Cardiac surgery
Aortic Aneurysm
Up-Regulation
body regions
Aortic Dissection
C-Reactive Protein
lcsh:RC666-701
030220 oncology & carcinogenesis
Predictive value of tests
Case-Control Studies
Acute Disease
biology.protein
Female
Cardiology and Cardiovascular Medicine
business
Biomarkers
Research Article
Zdroj: BMC Cardiovascular Disorders
BMC Cardiovascular Disorders, Vol 18, Iss 1, Pp 1-7 (2018)
ISSN: 1471-2261
Popis: Background Matrix metalloproteinase 9 (MMP9) and Toll-like receptor 4 (TLR4) play important roles in aortic pathophysiology. However, there is lacking research on serum TLR4 levels in acute aortic dissection (AAD) patients, and the performance of serum MMP9 and TLR4 for the diagnosis of AAD is still unknown. This study aimed to evaluate the serum levels of MMP9 and TLR4 in AAD patients, identify their associations with circulating C-reactive protein (CRP) and D-dimer, which are well-known classical biomarkers of AAD, and further explore the potential diagnostic role of MMP9 and TLR4 in AAD. Methods Serum levels of MMP9 and TLR4 were measured by enzyme-linked immunosorbent assay (ELISA) in 88 AAD patients and 88 controls. The clinical test related information was collected from patients’ electronic medical records. Results Serum MMP9 and TLR4 levels were significantly higher in AAD patients than those in healthy controls in the general and stratified comparisons. Either serum MMP9 or TLR4 was independently associated with the risk of AAD (all p
Databáze: OpenAIRE
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