BaGdF5 Nanophosphors Doped with Different Concentrations of Eu3+ for Application in X-ray Photodynamic Therapy
| Autor: | Daria Kirsanova, Zaira Gadzhimagomedova, Aleksey Yu Maksimov, V. A. Polyakov, Anna S. Goncharova, Alexander V. Soldatov, Mikhail A. Soldatov, Anna A. Belanova, D. V. Khodakova, Vera V. Butova, I. A. Pankin, Elizaveta Mukhanova |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
tumor
Materials science photosensitizer QH301-705.5 X-ray photodynamic therapy nanophosphor reactive oxygen species computed tomography scintillating nanoparticles Nanoparticle Catalysis Inorganic Chemistry chemistry.chemical_compound Photosensitizer Biology (General) Physical and Theoretical Chemistry QD1-999 Molecular Biology Spectroscopy Nanocomposite Organic Chemistry General Medicine Computer Science Applications Amorphous solid Chemistry chemistry Transmission electron microscopy Mesoporous material Methylene blue Nuclear chemistry Visible spectrum |
| Zdroj: | International Journal of Molecular Sciences; Volume 22; Issue 23; Pages: 13040 International Journal of Molecular Sciences, Vol 22, Iss 13040, p 13040 (2021) |
| ISSN: | 1422-0067 |
| DOI: | 10.3390/ijms222313040 |
| Popis: | X-ray photodynamic therapy (XPDT) has been recently considered as an efficient alternative to conventional radiotherapy of malignant tissues. Nanocomposites for XPDT typically consist of two components—a nanophosphor which re-emits X-rays into visible light that in turn is absorbed by the second component, a photosensitizer, for further generation of reactive oxygen species. In this study, BaGdF5 nanophosphors doped with different Eu:Gd ratios in the range from 0.01 to 0.50 were synthesized by the microwave route. According to transmission electron microscopy (TEM), the average size of nanophosphors was ~12 nm. Furthermore, different coatings with amorphous SiO2 and citrates were systematically studied. Micro-CT imaging demonstrated superior X-ray attenuation and sufficient contrast in the liver and the spleen after intravenous injection of citric acid-coated nanoparticles. In case of the SiO2 surface, post-treatment core–shell morphology was verified via TEM and the possibility of tunable shell size was reported. Nitrogen adsorption/desorption analysis revealed mesoporous SiO2 formation characterized by the slit-shaped type of pores that should be accessible for methylene blue photosensitizer molecules. It was shown that SiO2 coating subsequently facilitates methylene blue conjugation and results in the formation of the BaGdF5: 10% Eu3+@SiO2@MB nanocomposite as a promising candidate for application in XPDT. |
| Databáze: | OpenAIRE |
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