Validation of lung density indices by cardiac CT for quantification of lung emphysema
| Autor: | Klaus F. Kofoed, Jørgen Vestbo, Peter Lange, Børge G. Nordestgaard, Yunus Çolak, Thomas S. Kristensen, Jørgen Tobias Kühl, Anna Kalhauge, Susanne Dam Nielsen, Andreas Ronit |
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| Rok vydání: | 2018 |
| Předmět: |
lung density
Male Percentile Correlation coefficient Denmark Chest ct cardiac CT chest CT Comorbidity Coronary Artery Disease International Journal of Chronic Obstructive Pulmonary Disease 030204 cardiovascular system & hematology chronic obstructive pulmonary disease Pulmonary Disease Chronic Obstructive 03 medical and health sciences 0302 clinical medicine medicine Humans Lung emphysema Correlation of Data Vascular Calcification Lung Specific Gravity Original Research COPD Receiver operating characteristic business.industry Reproducibility of Results General Medicine Middle Aged respiratory system medicine.disease Coronary Vessels respiratory tract diseases Lung density Cardiac Imaging Techniques emphysema Concordance correlation coefficient Pulmonary Emphysema 030228 respiratory system Tomography X-Ray Computed Nuclear medicine business agreement |
| Zdroj: | International Journal of Chronic Obstructive Pulmonary Disease Ronit, A, Kristensen, T, Çolak, Y, Kühl, J T, Kalhauge, A, Lange, P, Nordestgaard, B, Vestbo, J, Nielsen, S & Kofoed, K F 2018, ' Validation of lung density indices by cardiac CT for quantification of lung emphysema ', International journal of chronic obstructive pulmonary disease, vol. Volume 13, pp. 3321-3330 . https://doi.org/10.2147/COPD.S172695 Ronit, A, Kristensen, T, Çolak, Y, Kühl, J T, Kalhauge, A, Lange, P, Nordestgaard, B, Vestbo, J, Nielsen, S & Kofoed, K F 2018, ' Validation of lung density indices by cardiac CT for quantification of lung emphysema ', International Journal of Chronic Obstructive Pulmonary Disease, vol. 13, pp. 3321-3330 . https://doi.org/10.2147/COPD.S172695 Ronit, A, Kristensen, T, Colak, Y, Kuhl, J T, Kalhauge, A, Lange, P, Nordestgaard, B G, Vestbo, J, Nielsen, S D & Kofoed, K F 2018, ' Validation of lung density indices by cardiac CT for quantification of lung emphysema ', International Journal of Chronic Obstructive Pulmonary Disease, vol. 13, pp. 3321-3330 . https://doi.org/10.2147/COPD.S172695 |
| ISSN: | 1178-2005 |
| Popis: | Objectives: Cardiovascular disease is often associated with COPD. Lung density quantification of images obtained from cardiac computed tomography (CT) scans would allow simultaneous evaluation of emphysema and coronary artery calcification score and provide further mechanistic insight into the relationship between these syndromes.Patients and methods: We assessed the agreement between lung density indices obtained by cardiac and full-lung CT scans. Paired cardiac and chest CT scans were assessed in 156 individuals with and without airflow limitation. Quantitative threshold indices of low attenuation area (LAA) and 15th percentile density index (PD15) were compared in terms of precision using Spearman’s correlation coefficient, accuracy using concordance correlation coefficient (CCC), and relative accuracy using P15 and P30. We also assessed the relationship between visually and quantitatively determined emphysema and used receiver operating characteristic curves to evaluate the ability of lung density indices to discriminate airflow limitation.Results: Correlation coefficients between lung density indices obtained from cardiac and chest CT scans were 0.49 for percent LAA (%LAA)-950 and 0.71 for PD15. Corresponding values for CCC, P15, and P30 were 0.33, 3.2, and 5.1, respectively, for %LAA-950, and 0.34, 17.3, and 37.8, respectively, for PD15. For both cardiac and chest CT scans, visually determined emphysema was associated with higher %LAA-950 and lower PD15, and the ability of %LAA-950 and PD15 to discriminate airflow limitation were comparable.Conclusion: Although chest CT imaging is preferable, cardiac CT imaging may also be used for lung emphysema quantification where association measures are of primary interest. Objectives: Cardiovascular disease is often associated with COPD. Lung density quantification of images obtained from cardiac computed tomography (CT) scans would allow simultaneous evaluation of emphysema and coronary artery calcification score and provide further mechanistic insight into the relationship between these syndromes.Patients and methods: We assessed the agreement between lung density indices obtained by cardiac and full-lung CT scans. Paired cardiac and chest CT scans were assessed in 156 individuals with and without airflow limitation. Quantitative threshold indices of low attenuation area (LAA) and 15th percentile density index (PD15) were compared in terms of precision using Spearman’s correlation coefficient, accuracy using concordance correlation coefficient (CCC), and relative accuracy using P15 and P30. We also assessed the relationship between visually and quantitatively determined emphysema and used receiver operating characteristic curves to evaluate the ability of lung density indices to discriminate airflow limitation.Results: Correlation coefficients between lung density indices obtained from cardiac and chest CT scans were 0.49 for percent LAA (%LAA)-950 and 0.71 for PD15. Corresponding values for CCC, P15, and P30 were 0.33, 3.2, and 5.1, respectively, for %LAA-950, and 0.34, 17.3, and 37.8, respectively, for PD15. For both cardiac and chest CT scans, visually determined emphysema was associated with higher %LAA-950 and lower PD15, and the ability of %LAA-950 and PD15 to discriminate airflow limitation were comparable.Conclusion: Although chest CT imaging is preferable, cardiac CT imaging may also be used for lung emphysema quantification where association measures are of primary interest. |
| Databáze: | OpenAIRE |
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