Effects of Continuously Feeding Diets Containing Cereal Ergot Alkaloids on Nutrient Digestibility, Alkaloid Recovery in Feces, and Performance Traits of Ram Lambs
| Autor: | Kim Stanford, John J McKinnon, Alexandre V. Chaves, Barry Blakley, Yuxi Wang, Tim A. McAllister, Stephanie Coufal-Majewski, M.L. Swift |
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| Rok vydání: | 2017 |
| Předmět: |
Male
0301 basic medicine Ergot Alkaloids endocrine system Ergosine growth Health Toxicology and Mutagenesis Ergocristine lcsh:Medicine epimer Biology Toxicology lambs complex mixtures 01 natural sciences Article Feces 03 medical and health sciences chemistry.chemical_compound Animal science Ergocryptine medicine Animals heterocyclic compounds Sheep ergot organic chemicals Alkaloid lcsh:R 010401 analytical chemistry Hordeum Metabolism alkaloid Animal Feed Diet 0104 chemical sciences 030104 developmental biology chemistry nutrient digestibility Ergotamine Edible Grain Medicago sativa Ergocornine medicine.drug |
| Zdroj: | Toxins; Volume 9; Issue 12; Pages: 405 Toxins Toxins, Vol 9, Iss 12, p 405 (2017) |
| ISSN: | 2072-6651 |
| DOI: | 10.3390/toxins9120405 |
| Popis: | Allowable limits for cereal ergot alkaloids in livestock feeds are being re-examined, and the objective of this study was to compare nutrient digestibility, growth performance and carcass characteristics of ram lambs fed a range of alkaloid concentrations, including the maximum currently allowed in Canada (2 to 3 ppm). Four pelleted diets were fed: control, with no added alkaloids; 930; 1402; and 2447 ppb alkaloids based on total R and S epimers. Eight ram lambs (30.0 ± 3.1 kg) were used to examine the impacts of dietary treatments on nutrient digestibility and alkaloid recovery from feces. Concentrations of dietary alkaloids evaluated did not affect nutrient digestibility or N metabolism. Excepting ergocornine and ergocryptine, recovery of alkaloids in feces varied among periods, suggesting that individual lambs may differ in their ability to metabolize ergocristine, ergometrine, ergosine, ergotamine and their S epimers. In a second experiment, ram lambs (n = 47, 30 ± 8 kg) were randomly assigned to a diet and weighed weekly until they achieved a slaughter weight of ≥ 45 kg (average 9 weeks; range 6 to 13 weeks). Intake of DM did not differ (p = 0.91) among diets, although lambs fed 2447 ppb alkaloids had a lower (p < 0.01) ADG than did lambs receiving other treatments. The concentration of serum prolactin linearly declined (p < 0.01) with increasing alkaloids. Feeding 2447 ppb total alkaloids negatively impacted growth, while feeding 1402 ppb did not harm growth performance, but reduced carcass dressing percentage. Due to different concentrations of alkaloids affecting growth and carcass characteristics in the present study, determining allowable limits for total dietary alkaloids will require a better understanding of impacts of alkaloid profiles and interactions among individual alkaloids. |
| Databáze: | OpenAIRE |
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