Anti-anaphylactic and bronchodilating action of a beta-adrenoceptor stimulator, KWD 2131, in human lung tissue
| Autor: | K. Strandberg, L. Sörenby, C. G. A. Persson, K‐O. Pegelow |
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| Rok vydání: | 1979 |
| Předmět: |
medicine.medical_specialty
Adrenergic receptor Immunology Terbutaline Bronchi Pharmacology In Vitro Techniques Histamine Release Human lung chemistry.chemical_compound Isoprenaline Internal medicine medicine Immunology and Allergy Potency Humans Inhibitory effect Anaphylaxis Lung Isoproterenol respiratory system Adrenergic beta-Agonists Allergens Bronchodilator Agents Endocrinology medicine.anatomical_structure chemistry Ethanolamines Pollen Histamine medicine.drug |
| Zdroj: | Allergy. 34(4) |
| ISSN: | 0105-4538 |
| Popis: | The beta-adrenoceptor stimulating agent KWD 2131 has been studied with regard to inhibitory effect on allergen-induced histamine release from passively sensitized human lung tissue and relaxing effect on contracted small (diameter = 1 mm) and large (diameter greater than 3 mm) isolated human bronchi. The dose for 50% inhibition of the allergen-induced histamine release was 2 x 10(-11) M. The potency of KWD 2131 was approximately 0.15 times that of terbutaline and 0.05 times that of isoprenaline in this respect. The bronchodilating potency of KWD 2131 was 0.02-0.03 times that of terbutaline. The data indicate that KWD 2131 is a compound with preferably anti-anaphylactic potency in the human lung. |
| Databáze: | OpenAIRE |
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