Childhood asthma outcomes during the COVID-19 pandemic: Findings from the PeARL multi-national cohort

Autor: Papadopoulos, Nikolaos G., Mathioudakis, Alexander G., Custovic, Adnan, Deschildre, Antoine, Phipatanakul, Wanda, Wong, Gary, Xepapadaki, Paraskevi, Abou‐taam, Rola, Agache, Ioana, Castro‐rodriguez, Jose A., Chen, Zhimin, Cros, Pierrick, Dubus, Jean‐christophe, El‐sayed, Zeinab Awad, El‐owaidy, Rasha, Feleszko, Wojciech, Fierro, Vincenzo, Fiocchi, Alessandro, Garcia‐marcos, Luis, Goh, Anne, Hossny, Elham M., Huerta Villalobos, Yunuen R., Jartti, Tuomas, Le Roux, Pascal, Levina, Julia, López García, Aida Inés, Ramos, Ángel Mazón, Morais‐almeida, Mário, Murray, Clare, Nagaraju, Karthik, Nagaraju, Major K., Navarrete Rodriguez, Elsy Maureen, Namazova‐baranova, Leyla, Nieto Garcia, Antonio, Pozo Beltrán, Cesar Fireth, Ratchataswan, Thanaporn, Rivero Yeverino, Daniela, Rodríguez Zagal, Eréndira, Schweitzer, Cyril E., Tulkki, Marleena, Wasilczuk, Katarzyna, Xu, Dan, Alekseeva, Anna, Almeida, Bethan, Andre, Maud, Arimova, Polina, Blonde, Aurore, Cunningham, Amparito, Da Mota, Sofia, Efendieva, Kamilla, Kalugina, Vera, Kiefer, Sébastien, Klein, Anais, López, Chrystopherson Gengyny Caballero, López, Juan Jesús Ríos, Moratellti, Caroline, Fuentes Pérez, Miguel, Simermann, Meryl, Tapia, José Sergio Papaqui, Tatopoulos, Aurelie, Vishneva, Elena, Volkov, Κonstantin, Bacharier, Leonard, Bonini, Matteo, Craig, Timothy, Diamant, Zuzana, Ducharme, Francine M, Gern, James E., Grigg, Jonathan, Hamelmann, Eckard H, Hedlin, Gunilla, Kalayci, Omer, Kaplan, Alan, Konradsen, Jon, Kuna, Piotr, Lau, Susanne, Le Souef, Peter, Lemanske, Robert F, Makela, Mika J, Matricardi, Paolo M, Gómez, René‐maximiliano, Miligkos, Michael, Pitrez, Paulo Mc, Price, David, Pohunek, Petr, Roberts, Graham C, Sheikh, Aziz, Tsiligianni, Ioanna, Turner, Steve, Valiulis, Arunas, Winders, Tonya, Yusuf, Osman M, Zar, Heather
Přispěvatelé: University of Manchester [Manchester], Pneumologie et allergologie pédiatriques [CHU Jeanne de Flandre, Lille], Hôpital Jeanne de Flandre [Lille], Université de Lille, The Chinese University of Hong Kong [Hong Kong], Department of Nutrition and Dietetics [Athens, Greece], Harokopio University [Athens, Greece], Transilvania University of Brasov, CHRU de Brest - Département de Pédiatrie (CHU BREST Pédiatrie), Centre Hospitalier Régional Universitaire de Brest (CHRU Brest), Microbes évolution phylogénie et infections (MEPHI), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Service de pédiatrie spécialisée et médecine infantile (neurologie, pneumologie, maladies héréditaires du métabolisme) [Hôpital de la Timone - APHM], Hôpital de la Timone [CHU - APHM] (TIMONE), Medical University of Warsaw - Poland, Bambino Gesù Children’s Hospital [Rome, Italy]
Jazyk: angličtina
Rok vydání: 2021
Předmět:
0301 basic medicine
Pediatrics
Allergy
coronavirus
CHILDREN
Pulmonary function testing
0302 clinical medicine
[SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases
immune system diseases
childhood asthma
Pandemic
Immunology and Allergy
Medicine
Outpatient clinic
Child
ComputingMilieux_MISCELLANEOUS
[SDV.MHEP.ME]Life Sciences [q-bio]/Human health and pathology/Emerging diseases
Respiratory tract infections
Minimal clinically important difference
PeARL collaborators
on behalf of the PeARL Think Tank
Hospitalization
1107 Immunology
Child
Preschool
[SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology
Cohort
Original Article
PEDIATRIC ASTHMA
COVID-19
Life Sciences & Biomedicine
medicine.medical_specialty
Coronavirus disease 2019 (COVID-19)
Adolescent
Immunology
VALIDATION
03 medical and health sciences
[SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system
COVID‐19
Humans
[SDV.MP.PAR]Life Sciences [q-bio]/Microbiology and Parasitology/Parasitology
Risk factor
Pandemics
Asthma
Childhood asthma
Science & Technology
SARS-CoV-2
business.industry
Original Articles
medicine.disease
[SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology
respiratory tract diseases
EXACERBATIONS
030104 developmental biology
030228 respiratory system
Emergency medicine
business
ACUTE RESPIRATORY SYNDROME
Zdroj: Papadopoulos, N G, Mathioudakis, A G, Custovic, A, Deschildre, A, Phipatanakul, W, Wong, G, Xepapadaki, P, Abou-taam, R, Agache, I, Castro-rodriguez, J A, Chen, Z, Cros, P, Dubus, J, El-sayed, Z A, El-owaidy, R, Feleszko, W, Fierro, V, Fiocchi, A, Garcia-marcos, L, Goh, A, Hossny, E M, Huerta Villalobos, Y R, Jartti, T, Le Roux, P, Levina, J, López García, A I, Ramos, Á M, Morais-almeida, M, Murray, C, Nagaraju, K, Nagaraju, M K, Navarrete Rodriguez, E M, Namazova-baranova, L, Nieto Garcia, A, Pozo Beltrán, C F, Ratchataswan, T, Rivero Yeverino, D, Rodríguez Zagal, E, Schweitzer, C E, Tulkki, M, Wasilczuk, K, Xu, D, Alekseeva, A, Almeida, B, Andre, M, Arimova, P, Blonde, A, Cunningham, A, Da Mota, S, Efendieva, K, Kalugina, V, Kiefer, S, Klein, A, López, C G C, López, J J R, Moratellti, C, Fuentes Pérez, M, Simermann, M, Tapia, J S P, Tatopoulos, A, Vishneva, E, Volkov, Κ, Bacharier, L, Bonini, M, Craig, T, Diamant, Z, Ducharme, F M, Gern, J E, Grigg, J, Hamelmann, E H, Hedlin, G, Jartti, T, Kalayci, O, Kaplan, A, Konradsen, J, Kuna, P, Lau, S, Le Souef, P, Lemanske, R F, Makela, M J, Matricardi, P M, Gómez, R, Miligkos, M, Pitrez, P M, Price, D, Pohunek, P, Roberts, G C, Sheikh, A, Tsiligianni, I, Turner, S, Valiulis, A, Winders, T, Yusuf, O M & Zar, H 2021, ' Childhood asthma outcomes during the COVID-19 pandemic: Findings from the PeARL multi-national cohort ', Allergy . https://doi.org/10.1111/all.14787
Allergy, Hoboken : John Wiley and Sons Inc, 2021, vol. 76, iss. 6, p. 1765-1775
Allergy
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
instname
Allergy, 2021, 76 (6), pp.1765-1775. ⟨10.1111/all.14787⟩
ISSN: 0105-4538
1398-9995
DOI: 10.1111/all.14787
Popis: Background The interplay between COVID‐19 pandemic and asthma in children is still unclear. We evaluated the impact of COVID‐19 pandemic on childhood asthma outcomes. Methods The PeARL multinational cohort included 1,054 children with asthma and 505 non‐asthmatic children aged between 4 and 18 years from 25 pediatric departments, from 15 countries globally. We compared the frequency of acute respiratory and febrile presentations during the first wave of the COVID‐19 pandemic between groups and with data available from the previous year. In children with asthma, we also compared current and historical disease control. Results During the pandemic, children with asthma experienced fewer upper respiratory tract infections, episodes of pyrexia, emergency visits, hospital admissions, asthma attacks, and hospitalizations due to asthma, in comparison with the preceding year. Sixty‐six percent of asthmatic children had improved asthma control while in 33% the improvement exceeded the minimal clinically important difference. Pre‐bronchodilatation FEV1 and peak expiratory flow rate were improved during the pandemic. When compared to non‐asthmatic controls, children with asthma were not at increased risk of LRTIs, episodes of pyrexia, emergency visits, or hospitalizations during the pandemic. However, an increased risk of URTIs emerged. Conclusion Childhood asthma outcomes, including control, were improved during the first wave of the COVID‐19 pandemic, probably because of reduced exposure to asthma triggers and increased treatment adherence. The decreased frequency of acute episodes does not support the notion that childhood asthma may be a risk factor for COVID‐19. Furthermore, the potential for improving childhood asthma outcomes through environmental control becomes apparent.
This study evaluates the frequency of acute respiratory and febrile presentations furing the first wave of COVID‐19 pandemic in childhood asthma. Data from the multinational PeARL cohort reveal improved health and asthma activity during the first wave of the COVID‐19 pandemic, probably attributed to decreased exposure to asthma triggers and increased treatment adherence. During that period, children with asthma experienced fewer URTIs, episodes of pyrexia, emergency visits, hospital admissions, asthma attacks and hospitalizations due to asthma, in comparison to the preceding year.
Databáze: OpenAIRE
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