Fulminant hepatic failure in an African setting: etiology, clinical course, and predictors of mortality
| Autor: | B. A. Yousif, H. M. Y. Mudawi |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Adult
Male medicine.medical_specialty Hepatitis Viral Human Physiology Autoimmune hepatitis medicine.disease_cause Antibodies Viral Gastroenterology Sudan Fulminant hepatic failure Orthohepadnavirus Hepatitis E virus Internal medicine Hepatitis Viruses medicine Humans Prospective Studies Aged Hepatitis Hepatitis B virus biology business.industry Hepatitis A Hepatology Liver Failure Acute Middle Aged medicine.disease biology.organism_classification Prognosis Survival Rate Cross-Sectional Studies Antibodies Antinuclear Immunology Female business Follow-Up Studies |
| Zdroj: | Digestive diseases and sciences. 52(11) |
| ISSN: | 0163-2116 |
| Popis: | This is prospective cross-sectional study on 37 patients presenting to different hospitals in Khartoum state, Sudan, sought to determine the etiology, clinical course, and predictors of mortality in patients presenting with fulminant hepatic failure (FHF). Patients were subclassified into hyperacute, acute, and subacute FHF; all sera were tested for hepatitis A, B, C, and E; negative samples were tested for antinuclear antibodies and anti-smooth muscle antibodies. The commonest etiologic factors included seronegative hepatitis (38%), hepatitis B virus (22%), severe Plasmodium falciparum malaria (8%), autoimmune hepatitis (8%), hepatitis E virus (5%), anti-tuberculous drugs (5%), and lymphomatous infiltration of the liver (5%). The mortality rate was high at 84%. Poor prognostic factors included presentation with grade III/IV encephalopathy, evidence of bacterial infection, and a prolonged prothrombin time of >25 seconds over the controls. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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