Evaluation of Serum Levels and Expression of Galectin-4 in Cervical Cancer
| Autor: | Maricruz Anaya-Ruiz, Gustavo Lopez-Lopez, Aurelio López-Colombo, Francisco Javier Ceja-Utrera, Guadalupe Delgado-Lopez, Julio Reyes-Leyva, Juan Carlos Flores-Alonso, Erick Armenta-Castro, Salvador Reyes-Salinas, Verónica Vallejo-Ruiz, Victor Javier Vazquez-Zamora, Claudia T. Gutiérrez-Quiroz, Ivonne Ramírez-Díaz, Ileana Conde-Rodríguez |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Cervical cancer
Pathology medicine.medical_specialty General Immunology and Microbiology Article Subject business.industry Cancer General Medicine Subcellular localization medicine.disease General Biochemistry Genetics and Molecular Biology Metastasis stomatognathic diseases Cytoplasm otorhinolaryngologic diseases Medicine Immunohistochemistry Adenocarcinoma Stage (cooking) business |
| Zdroj: | BioMed Research International, Vol 2020 (2020) |
| ISSN: | 2314-6133 |
| DOI: | 10.1155/2020/6756723 |
| Popis: | Galectin-4 has been reported to be altered in different cancer types. Its expression changes have been associated with early recurrence and metastasis. In cervical cancer (CC), galectin-4 has not been studied. The aim of the study was to determine the expression level and subcellular localization of galectin-4 in CC tissue and the concentration in the serum of patients with CC. For the analysis of serum levels of galectin-4, an ELISA assay was performed. To assess the expression in cervical tissue, immunohistochemical staining was performed. The results showed that the concentration of galectin-4 in the serum of patients with CC was higher (647.9 pg/ml) than that in the serum of women with normal cytology (382.1 pg/ml). The immunohistochemical analysis of CC samples showed a higher expression in keratinizing tumor than nonkeratinizing tumors and a trend of increased expression in tumors from patients with advanced clinical stage. In normal cervical tissue, galectin-4 was detected in the cytoplasm, and in tumor cells, the presence of galectin-4 was also detected in the nucleus, in both adenocarcinoma and squamous cervical cancer. The increase in serum concentration and different localization in the tumor cells suggest a possible role of galectin-4 in CC development. |
| Databáze: | OpenAIRE |
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