Determinants of persistent post-COVID-19 symptoms: value of a novel COVID-19 symptom score

Autor: Mohamed M Moustafa, Maiada K. Hashem, Abdel Rahman Ezzat, Hossam Eldeen E Zayan, Howida K. Abd_Elaal, Enas Fathy, Radwa Ed Helmy, Asmaa Mohammed Ismail, Karima M. S. Kholief, Nasrallah A. Al Massry, Mustafa Z Abdelsayed, Mahmoud M Saad, Aliae A. R. Mohamed Hussein, Mohamed A. Soliman, Mariam T. Amin, Islam Galal
Rok vydání: 2021
Předmět:
Zdroj: The Egyptian Journal of Bronchology
The Egyptian Journal of Bronchology, Vol 15, Iss 1, Pp 1-8 (2021)
ISSN: 2314-8551
1687-8426
DOI: 10.1186/s43168-020-00049-4
Popis: Background Being a newly emerging disease, little is known about its long-lasting post-COVID-19 consequences. The aim of this work is to assess the frequency, patterns, and determinants of persistent post-COVID-19 symptoms and to evaluate the value of a proposed novel COVID-19 symptom score. Patients with confirmed COVID-19 in a hospital-based registry were included in a cross-sectional study (the hospitals including Assiut University Hospital, Assiut Chest Hospital, Aswan University Hospital, and Aswan Specialized Hospital). The patient demographics, comorbid disorders, the mean duration since the onset of the symptoms, history of hospital or ICU admittance, and the treatment taken during the acute state, as well as symptom score before and after convalescence, were recorded. Results The most frequent constitutional and neurological symptoms were myalgia (60.0%), arthralgia (57.2%), restriction of daily activities (57.0%), and sleeping troubles (50.9%), followed by anorexia (42.6%), chest pain (32.6%), gastritis (32.3%), cough (29.3%), and dyspnea (29.1%). The mean total score of acute stage symptoms was 31.0 ± 16.3 while post-COVID 19 symptom score was 13.1 ± 12.6 (P P P = 0.039), chronic pulmonary disorders (P = 0.012), and any chronic comorbidity (P = 0.004). There was a correlation between the symptom score during the acute attack and post-COVID-19 stage (P r = 0.67). The acute phase score had 83.5% sensitivity and 73.3% specificity for the cutoff point > 18 to predict occurrence of post-COVID-19 symptoms. Conclusions COVID-19 can present with a diverse spectrum of long-term post-COVID-19 symptoms. Increased acute phase symptom severity and COVID-19 symptom score > 18 together with the presence of any comorbid diseases increase the risk for persistent post-COVID-19 manifestations and severity.
Databáze: OpenAIRE
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