No correlation between the variants of exostosin 2 gene and type 2 diabetes in Burkina Faso population
Autor: | Issoufou Nagabila, Serge Yannick Ouedraogo, Abel Pegdwendé Sorgho, Jonas Koudougou Kologo, Florencia Wendkuuni Djigma, Herman Karim Sombie, Dorcas Obiri-Yeboah, Moutanou Modeste Judes Zeye, Daméhan Tchelougou, Serge Théophile Soubeiga, Albert Théophane Yonli, Jacques Simpore, Abdoul Karim Ouattara, Rebeca Tegwindé Compaore |
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Jazyk: | angličtina |
Rok vydání: | 2020 |
Předmět: |
0301 basic medicine
Population Single-nucleotide polymorphism Type 2 diabetes Biology Article 03 medical and health sciences 0302 clinical medicine Statistical significance Burkina Faso TaqMan medicine 030212 general & internal medicine education Genotyping Genetic association Genetics education.field_of_study lcsh:Public aspects of medicine Public Health Environmental and Occupational Health association lcsh:RA1-1270 medicine.disease Type 2 Diabetes Minor allele frequency 030104 developmental biology Exostosin-2 SNPs |
Zdroj: | Journal of Public Health in Africa, Vol 11, Iss 1 (2020) Journal of Public Health in Africa |
ISSN: | 2038-9930 2038-9922 |
Popis: | Recent genome-wide association studies and replication analyses have reported the association of variants of the exostosin- 2 gene (EXT2) and risk of type 2 diabetes (T2D) in some populations, but not in others. This study aimed to characterize the variants rs1113132, rs3740878 and rs11037909 of EXT2 and to determine the existence of a possible correlation with T2D in Burkina Faso. It is a case-control study undertaken in Burkina Faso in the city of Ouagadougou at the Hospital of Saint Camille of Ouagadougou from December 2014 to June 2015. It relates to 121 type 2 diabetes cases and 134 controls. The genotyping of these polymorphisms was done by real-time PCR using the allelic exclusion method with TaqMan probes. The minor allele frequencies (MAFs) was almost identical in diabetic and control subjects for the all three Single Nucleotide Polymorphisms (SNPs) with no statistical significance, p>0.05: rs1113132 (OR=0.89; p=0.82); rs11037909 (OR=0.89; p=0.74) and rs3740878 (OR=1.52; p=0.42). None of the three polymorphisms studied was associated with the risk of DT2. However, an association between the BMI, age and type 2 diabetes was noted. The variants of EXT2 would not be associated to the risk of T2D in the African black population of Burkina Faso. |
Databáze: | OpenAIRE |
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