Isolation of cepafungins I, II and III from Pseudomonas species
| Autor: | Katsuya Tawara, Keiichiro Hirooka, Jun'ichi Shoji, Toshiyuki Kato, Teruo Hattori, Hiroshi Hinoo, Osamu Shiratori, Yoshihiro Terui |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Antifungal Agents
Magnetic Resonance Spectroscopy Spectrophotometry Infrared medicine.drug_class Stereochemistry Antibiotics Melanoma Experimental Peptides Cyclic Microbiology chemistry.chemical_compound Mice Pseudomonas Yeasts Drug Discovery medicine Animals Leukemia L1210 Chromatography High Pressure Liquid Pharmacology Antibiotics Antineoplastic Leukemia Experimental biology Dimethyl sulfoxide Leukemia P388 Fungi Biological activity biology.organism_classification Yeast chemistry Pseudomonadales Spectrophotometry Ultraviolet Bacteria Pseudomonadaceae |
| Zdroj: | The Journal of antibiotics. 43(7) |
| ISSN: | 0021-8820 |
| Popis: | New acylpeptide antibiotics named cepafungins I, II and III were isolated from the culture broth of a strain identified as Pseudomonas sp. These antibiotics are neutral substances, soluble in aqueous alcohols and dimethyl sulfoxide, and show UV maxima at 260.5 nm. The IR spectra indicated these to be peptides. Molecular formulas C28H46N4O6, C27H44N4O6 and C26H42N4O6 for cepafungins I, II and III were indicated by elemental analysis and SI-MS. Cepafungins exhibited inhibitory activity against yeast and fungi, and antitumor activity against P388 leukemia in mice. |
| Databáze: | OpenAIRE |
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